A retrospective single center analysis of fetuses with region of homozygosity detected by single nucleotide polymorphism array

A retrospective single center analysis of fetuses with region of homozygosity detected by single nucleotide polymorphism array

Abstract We assessed the incidence and clinical significance of the fetal region of homozygosity (ROH) detected using single nucleotide polymorphism (SNP) array by analyzing clinical information and pregnancy outcomes. We collected data on 6176 mid- and late pregnancies. All fetuses were subjected t...

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Bibliographic Details
Main Authors: Xiufen Bu, Xiuyun Yu, Li Zeng, Guo Zeng, Rong Tan, Can Peng, Shihao Zhou, Siyuan Linpeng, Jing Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Region of homozygosity
SNP array
Mid- and late pregnancy
Uniparental disomy
Prenatal diagnosis
Online Access:https://doi.org/10.1038/s41598-025-98497-9
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https://doi.org/10.1038/s41598-025-98497-9

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