Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin
Primary biliary cirrhosis (PBC) is associated with immune-mediated dermatologic disorders. The association of PBC with erythema nodosum (EN) seems rare. We report two females (42 and 44 years old) with low-grade fever, arthralgias, and elevated cholestatic enzymes in the first and fatigue in the sec...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/121620 |
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| author | Nikolaos K. Gatselis Kalliopi Zachou George N. Dalekos |
| author_facet | Nikolaos K. Gatselis Kalliopi Zachou George N. Dalekos |
| author_sort | Nikolaos K. Gatselis |
| collection | DOAJ |
| description | Primary biliary cirrhosis (PBC) is associated with immune-mediated dermatologic disorders. The association of PBC with erythema nodosum (EN) seems rare. We report two females (42 and 44 years old) with low-grade fever, arthralgias, and elevated cholestatic enzymes in the first and fatigue in the second. Patients were also suffering from typical EN lesions characterized by multiple erythematous, painful nodules over the anterior portions of their lower extremities. Clinical and extensive laboratory work up excluded all known EN causes. PBC diagnosis was established according to the cholestatic biochemical profile, anti-mitochondrial antibodies (AMA) positivity and liver histology (first), and AMA and antinuclear (ANA) PBC-specific antibodies (second). Our report may suggest that PBC could be kept in mind in EN patients of unknown aetiology and particularly, when middle-aged female patients are affected. In such cases a thorough evaluation for AMA and/or ANA PBC-specific antibodies could be helpful to achieve a correct and timely diagnosis. |
| format | Article |
| id | doaj-art-9b31f245c53a498483e4bdd922e2b897 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-9b31f245c53a498483e4bdd922e2b8972025-02-03T06:14:09ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/121620121620Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown OriginNikolaos K. Gatselis0Kalliopi Zachou1George N. Dalekos2Department of Medicine, School of Medicine, University of Thessaly, Thessaly, 41110 Larissa, GreeceDepartment of Medicine, School of Medicine, University of Thessaly, Thessaly, 41110 Larissa, GreeceDepartment of Medicine, School of Medicine, University of Thessaly, Thessaly, 41110 Larissa, GreecePrimary biliary cirrhosis (PBC) is associated with immune-mediated dermatologic disorders. The association of PBC with erythema nodosum (EN) seems rare. We report two females (42 and 44 years old) with low-grade fever, arthralgias, and elevated cholestatic enzymes in the first and fatigue in the second. Patients were also suffering from typical EN lesions characterized by multiple erythematous, painful nodules over the anterior portions of their lower extremities. Clinical and extensive laboratory work up excluded all known EN causes. PBC diagnosis was established according to the cholestatic biochemical profile, anti-mitochondrial antibodies (AMA) positivity and liver histology (first), and AMA and antinuclear (ANA) PBC-specific antibodies (second). Our report may suggest that PBC could be kept in mind in EN patients of unknown aetiology and particularly, when middle-aged female patients are affected. In such cases a thorough evaluation for AMA and/or ANA PBC-specific antibodies could be helpful to achieve a correct and timely diagnosis.http://dx.doi.org/10.1155/2010/121620 |
| spellingShingle | Nikolaos K. Gatselis Kalliopi Zachou George N. Dalekos Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin Gastroenterology Research and Practice |
| title | Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin |
| title_full | Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin |
| title_fullStr | Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin |
| title_full_unstemmed | Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin |
| title_short | Early Primary Biliary Cirrhosis: A New Association with Erythema Nodosum of Unknown Origin |
| title_sort | early primary biliary cirrhosis a new association with erythema nodosum of unknown origin |
| url | http://dx.doi.org/10.1155/2010/121620 |
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