Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data

Establishing the best step-up treatments for children with uncontrolled asthma despite inhaled corticosteroids: the EINSTEIN systematic review, network meta-analysis and cost-effectiveness analysis using individual participant data

Background There is no clear preferential option for initial step-up of treatment for children with uncontrolled asthma on inhaled corticosteroid. Objectives Evaluate the clinical effectiveness of pharmacological treatments to use in children with uncontrolled asthma on inhaled corticosteroid; ident...

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Bibliographic Details
Main Authors: Sofia Cividini, Ian Sinha, Giovanna Culeddu, Sarah Donegan, Michelle Maden, Katie Rose, Olivia Fulton, Dyfrig Hughes, Stephen Turner, Catrin Tudur Smith
Format: Article
Language:English
Published: NIHR Journals Library 2025-05-01
Series:Health Technology Assessment
Subjects:
systematic review
network meta-analysis
nma
individual participant data
ipd
network meta-regression
randomised clinical trials
economic evaluation
cost-effectiveness analysis
asthma
respiratory medicine
children
adolescents
paediatrics
inhaled corticosteroids
antiasthmatic agents
exacerbation
asthma attack
asthma control
spirometry
Online Access:https://doi.org/10.3310/HGWT3617
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https://doi.org/10.3310/HGWT3617

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