Gut microbiota links to histological damage in chronic HBV infection patients and aggravates fibrosis via fecal microbiota transplantation in mice

Gut microbiota links to histological damage in chronic HBV infection patients and aggravates fibrosis via fecal microbiota transplantation in mice

ABSTRACT Gut microbiota dysbiosis has been observed in HBV-related cirrhosis, but its role in early-stage disease and its correlation with liver pathology remain unclear. Moreover, whether dysbiosis is a cause or consequence of liver cirrhosis is still debated. We recruited 20 treatment-naïve patien...

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Main Authors: Fengjiao Wang, Yechen Wu, Jiali NI, Qianhan Xie, Jian Shen, Hui Chen, Chengyu Ma, Yuanyuan Yao, Jinzhi Wang, Lvwan Xu, Qiangqiang Xiang, Yuxi Zhao, Yanfei Chen, Lanjuan Li
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
HBV
liver biopsy
fecal microbiome transplantation
gut microbiota
liver fibrosis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00764-25
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https://journals.asm.org/doi/10.1128/spectrum.00764-25

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