The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis
The role of the process of apoptosis is investigated in the pathogenesis of many autoimmune diseases; however at present, there is not much information about its role in dermatitis herpetiformis. Skin biopsies were taken from 18 DH patients and from 10 healthy subjects. The localization and expressi...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/178340 |
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| author | Zebrowska Agnieszka Erkiert-Polguj Anna Wagrowska-Danilewicz Malgorzata Danilewicz Marian Sysa-Jedrzejowska Anna Anna Cynkier Waszczykowska Elzbieta |
| author_facet | Zebrowska Agnieszka Erkiert-Polguj Anna Wagrowska-Danilewicz Malgorzata Danilewicz Marian Sysa-Jedrzejowska Anna Anna Cynkier Waszczykowska Elzbieta |
| author_sort | Zebrowska Agnieszka |
| collection | DOAJ |
| description | The role of the process of apoptosis is investigated in the pathogenesis of many autoimmune diseases; however at present, there is not much information about its role in dermatitis herpetiformis. Skin biopsies were taken from 18 DH patients and from 10 healthy subjects. The localization and expression of Bax, Fas, FasL, TRAIL, TRAIL-R in skin lesions, and perilesional skin were studied by immunohistochemistry. Expression of Bax, Fas, and Fas ligand was detected in the keratinocytes in skin biopsies from DH patients. Expression of TRAIL and TRAIL receptor was confirmed in epidermis, infiltration cells, and some fibroblasts. The expression of examined molecules in biopsies from healthy people was observed only in single cells. There were statistically significant differences between lesional, perilesional, and healthy skin of control group in Bax expression analysis and between lesional skin and control group in Fas, FasL, and TRAIL expression. There were statistically significant differences between control group and perilesional skin in Bax and FasL expression. Our results show that selected proapoptotic molecules may take part in pathogenesis of dermatitis herpetiformis, but the role of apoptosis in this process is not clear. |
| format | Article |
| id | doaj-art-9aec229b5f6f411ab59a8397cd24beac |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-9aec229b5f6f411ab59a8397cd24beac2025-02-03T01:22:00ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/178340178340The Expression of Selected Proapoptotic Molecules in Dermatitis HerpetiformisZebrowska Agnieszka0Erkiert-Polguj Anna1Wagrowska-Danilewicz Malgorzata2Danilewicz Marian3Sysa-Jedrzejowska Anna4Anna Cynkier5Waszczykowska Elzbieta6Department of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka Street no. 5, 94-017 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka Street no. 5, 94-017 Lodz, PolandLaboratory of Nephropathology, Medical University of Lodz, Pomorska street no. 251, 92-216 Lodz, PolandLaboratory of Nephropathology, Medical University of Lodz, Pomorska street no. 251, 92-216 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka Street no. 5, 94-017 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka Street no. 5, 94-017 Lodz, PolandDepartment of Dermatology and Venereology, Medical University of Lodz, Krzemieniecka Street no. 5, 94-017 Lodz, PolandThe role of the process of apoptosis is investigated in the pathogenesis of many autoimmune diseases; however at present, there is not much information about its role in dermatitis herpetiformis. Skin biopsies were taken from 18 DH patients and from 10 healthy subjects. The localization and expression of Bax, Fas, FasL, TRAIL, TRAIL-R in skin lesions, and perilesional skin were studied by immunohistochemistry. Expression of Bax, Fas, and Fas ligand was detected in the keratinocytes in skin biopsies from DH patients. Expression of TRAIL and TRAIL receptor was confirmed in epidermis, infiltration cells, and some fibroblasts. The expression of examined molecules in biopsies from healthy people was observed only in single cells. There were statistically significant differences between lesional, perilesional, and healthy skin of control group in Bax expression analysis and between lesional skin and control group in Fas, FasL, and TRAIL expression. There were statistically significant differences between control group and perilesional skin in Bax and FasL expression. Our results show that selected proapoptotic molecules may take part in pathogenesis of dermatitis herpetiformis, but the role of apoptosis in this process is not clear.http://dx.doi.org/10.1155/2012/178340 |
| spellingShingle | Zebrowska Agnieszka Erkiert-Polguj Anna Wagrowska-Danilewicz Malgorzata Danilewicz Marian Sysa-Jedrzejowska Anna Anna Cynkier Waszczykowska Elzbieta The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis Clinical and Developmental Immunology |
| title | The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis |
| title_full | The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis |
| title_fullStr | The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis |
| title_full_unstemmed | The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis |
| title_short | The Expression of Selected Proapoptotic Molecules in Dermatitis Herpetiformis |
| title_sort | expression of selected proapoptotic molecules in dermatitis herpetiformis |
| url | http://dx.doi.org/10.1155/2012/178340 |
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