The ACE2/Apelin Signaling, MicroRNAs, and Hypertension
The renin-angiotensin aldosterone system (RAAS) plays a pivotal role in the development of hypertension. Angiotensin converting enzyme 2 (ACE2), which primarily metabolises angiotensin (Ang) II to generate the beneficial heptapeptide Ang-(1-7), serves as a negative regulator of the RAAS. Apelin is a...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2015/896861 |
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| author | Lai-Jiang Chen Ran Xu Hui-Min Yu Qing Chang Jiu-Chang Zhong |
| author_facet | Lai-Jiang Chen Ran Xu Hui-Min Yu Qing Chang Jiu-Chang Zhong |
| author_sort | Lai-Jiang Chen |
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| description | The renin-angiotensin aldosterone system (RAAS) plays a pivotal role in the development of hypertension. Angiotensin converting enzyme 2 (ACE2), which primarily metabolises angiotensin (Ang) II to generate the beneficial heptapeptide Ang-(1-7), serves as a negative regulator of the RAAS. Apelin is a second catalytic substrate for ACE2 and functions as an inotropic and cardiovascular protective peptide. The physiological effects of Apelin are exerted through binding to its receptor APJ, a seven-transmembrane G protein-coupled receptor that shares significant homology with the Ang II type 1 receptor (AT1R). The deregulation of microRNAs, a class of short and small noncoding RNAs, has been shown to involve cardiovascular remodeling and pathogenesis of hypertension via the activation of the Ang II/AT1R pathway. MicroRNAs are linked with modulation of the ACE2/Apelin signaling, which exhibits beneficial effects in the cardiovascular system and hypertension. The ACE2-coupled crosstalk among the RAAS, the Apelin system, and microRNAs provides an important mechanistic insight into hypertension. This paper focuses on what is known about the ACE2/Apelin signaling and its biological roles, paying particular attention to interactions and crosstalk among the ACE2/Apelin signaling, microRNAs, and hypertension, aiming to facilitate the exploitation of new therapeutic medicine to control hypertension. |
| format | Article |
| id | doaj-art-9abdb3c5b7364d43b3316e184e41d1f5 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-9abdb3c5b7364d43b3316e184e41d1f52025-02-03T05:48:26ZengWileyInternational Journal of Hypertension2090-03842090-03922015-01-01201510.1155/2015/896861896861The ACE2/Apelin Signaling, MicroRNAs, and HypertensionLai-Jiang Chen0Ran Xu1Hui-Min Yu2Qing Chang3Jiu-Chang Zhong4State Key Laboratory of Medical Genomics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, ChinaState Key Laboratory of Medical Genomics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, ChinaDepartment of Cardiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, ChinaState Key Laboratory of Medical Genomics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, ChinaState Key Laboratory of Medical Genomics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, ChinaThe renin-angiotensin aldosterone system (RAAS) plays a pivotal role in the development of hypertension. Angiotensin converting enzyme 2 (ACE2), which primarily metabolises angiotensin (Ang) II to generate the beneficial heptapeptide Ang-(1-7), serves as a negative regulator of the RAAS. Apelin is a second catalytic substrate for ACE2 and functions as an inotropic and cardiovascular protective peptide. The physiological effects of Apelin are exerted through binding to its receptor APJ, a seven-transmembrane G protein-coupled receptor that shares significant homology with the Ang II type 1 receptor (AT1R). The deregulation of microRNAs, a class of short and small noncoding RNAs, has been shown to involve cardiovascular remodeling and pathogenesis of hypertension via the activation of the Ang II/AT1R pathway. MicroRNAs are linked with modulation of the ACE2/Apelin signaling, which exhibits beneficial effects in the cardiovascular system and hypertension. The ACE2-coupled crosstalk among the RAAS, the Apelin system, and microRNAs provides an important mechanistic insight into hypertension. This paper focuses on what is known about the ACE2/Apelin signaling and its biological roles, paying particular attention to interactions and crosstalk among the ACE2/Apelin signaling, microRNAs, and hypertension, aiming to facilitate the exploitation of new therapeutic medicine to control hypertension.http://dx.doi.org/10.1155/2015/896861 |
| spellingShingle | Lai-Jiang Chen Ran Xu Hui-Min Yu Qing Chang Jiu-Chang Zhong The ACE2/Apelin Signaling, MicroRNAs, and Hypertension International Journal of Hypertension |
| title | The ACE2/Apelin Signaling, MicroRNAs, and Hypertension |
| title_full | The ACE2/Apelin Signaling, MicroRNAs, and Hypertension |
| title_fullStr | The ACE2/Apelin Signaling, MicroRNAs, and Hypertension |
| title_full_unstemmed | The ACE2/Apelin Signaling, MicroRNAs, and Hypertension |
| title_short | The ACE2/Apelin Signaling, MicroRNAs, and Hypertension |
| title_sort | ace2 apelin signaling micrornas and hypertension |
| url | http://dx.doi.org/10.1155/2015/896861 |
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