Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression
Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and p...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7373921 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556285720002560 |
|---|---|
| author | Carolina Cubillos-Zapata Enrique Hernández-Jiménez José Avendaño-Ortiz Victor Toledano Anibal Varela-Serrano Isabel Fernández-Navarro Raquel Casitas Carlos Carpio Luis A. Aguirre Francisco García-Río Eduardo López-Collazo |
| author_facet | Carolina Cubillos-Zapata Enrique Hernández-Jiménez José Avendaño-Ortiz Victor Toledano Anibal Varela-Serrano Isabel Fernández-Navarro Raquel Casitas Carlos Carpio Luis A. Aguirre Francisco García-Río Eduardo López-Collazo |
| author_sort | Carolina Cubillos-Zapata |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors. Both OSA and healthy monocytes have been found to show enhanced HIF1α expression under IH. Moreover, these cells under IH polarize toward a tumor-promoting phenotype in a HIF1α-dependent manner and influence tumor growth via vascular endothelial growth factor (VEGF). Monocytes from patients with OSA increased the tumor-induced microenvironment and exhibited an impaired cytotoxicity in a 3D tumor in vitro model as a result of the increased HIF1α secretion. Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context. |
| format | Article |
| id | doaj-art-9a4fdaca3fd241818ac3347d8bb3310c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9a4fdaca3fd241818ac3347d8bb3310c2025-02-03T05:45:52ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/73739217373921Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor ProgressionCarolina Cubillos-Zapata0Enrique Hernández-Jiménez1José Avendaño-Ortiz2Victor Toledano3Anibal Varela-Serrano4Isabel Fernández-Navarro5Raquel Casitas6Carlos Carpio7Luis A. Aguirre8Francisco García-Río9Eduardo López-Collazo10The Innate Immune Response Group, Tumor Immunology Lab, IdiPAZ, La Paz University Hospital, Madrid, SpainThe Innate Immune Response Group, Tumor Immunology Lab, IdiPAZ, La Paz University Hospital, Madrid, SpainThe Innate Immune Response Group, Tumor Immunology Lab, IdiPAZ, La Paz University Hospital, Madrid, SpainThe Innate Immune Response Group, Tumor Immunology Lab, IdiPAZ, La Paz University Hospital, Madrid, SpainThe Innate Immune Response Group, Tumor Immunology Lab, IdiPAZ, La Paz University Hospital, Madrid, SpainCenter for Biomedical Research Network of Respiratory Diseases (CIBERES), Madrid, SpainCenter for Biomedical Research Network of Respiratory Diseases (CIBERES), Madrid, SpainCenter for Biomedical Research Network of Respiratory Diseases (CIBERES), Madrid, SpainThe Innate Immune Response Group, Tumor Immunology Lab, IdiPAZ, La Paz University Hospital, Madrid, SpainCenter for Biomedical Research Network of Respiratory Diseases (CIBERES), Madrid, SpainThe Innate Immune Response Group, Tumor Immunology Lab, IdiPAZ, La Paz University Hospital, Madrid, SpainObstructive sleep apnea (OSA) is a syndrome characterized by repeated pauses in breathing induced by a partial or complete collapse of the upper airways during sleep. Intermittent hypoxia (IH), a hallmark characteristic of OSA, has been proposed to be a major determinant of cancer development, and patients with OSA are at a higher risk of tumors. Both OSA and healthy monocytes have been found to show enhanced HIF1α expression under IH. Moreover, these cells under IH polarize toward a tumor-promoting phenotype in a HIF1α-dependent manner and influence tumor growth via vascular endothelial growth factor (VEGF). Monocytes from patients with OSA increased the tumor-induced microenvironment and exhibited an impaired cytotoxicity in a 3D tumor in vitro model as a result of the increased HIF1α secretion. Adequate oxygen restoration both in vivo (under continuous positive airway pressure treatment, CPAP) and in vitro leads the monocytes to revert the tumor-promoting phenotype, demonstrating the plasticity of the innate immune system and the oxygen recovery relevance in this context.http://dx.doi.org/10.1155/2018/7373921 |
| spellingShingle | Carolina Cubillos-Zapata Enrique Hernández-Jiménez José Avendaño-Ortiz Victor Toledano Anibal Varela-Serrano Isabel Fernández-Navarro Raquel Casitas Carlos Carpio Luis A. Aguirre Francisco García-Río Eduardo López-Collazo Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression Mediators of Inflammation |
| title | Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression |
| title_full | Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression |
| title_fullStr | Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression |
| title_full_unstemmed | Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression |
| title_short | Obstructive Sleep Apnea Monocytes Exhibit High Levels of Vascular Endothelial Growth Factor Secretion, Augmenting Tumor Progression |
| title_sort | obstructive sleep apnea monocytes exhibit high levels of vascular endothelial growth factor secretion augmenting tumor progression |
| url | http://dx.doi.org/10.1155/2018/7373921 |
| work_keys_str_mv | AT carolinacubilloszapata obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT enriquehernandezjimenez obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT joseavendanoortiz obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT victortoledano obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT anibalvarelaserrano obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT isabelfernandeznavarro obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT raquelcasitas obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT carloscarpio obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT luisaaguirre obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT franciscogarciario obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression AT eduardolopezcollazo obstructivesleepapneamonocytesexhibithighlevelsofvascularendothelialgrowthfactorsecretionaugmentingtumorprogression |