Effects of piperine on intestinal permeation, pharmacodynamics and pharmacokinetics of insulin loaded chitosan coated solid lipid nanoparticles in rats

Effects of piperine on intestinal permeation, pharmacodynamics and pharmacokinetics of insulin loaded chitosan coated solid lipid nanoparticles in rats

Abstract The oral administration of insulin offers significant clinical benefits due to its simplicity. This study evaluated piperine’s efficacy in improving insulin’s intestinal absorption in Wistar rats. Confocal microscopy demonstrated that prolonged retention of insulin-loaded chitosan-coated so...

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Main Authors: Indu Raghunath, Marina Koland, Suprit D. Saoji, Sarad Pawar Naik Bukke, N. Shridhar Deshpande, Varsha Augustin, Nilesh Rarokar, Chandrashekar Thalluri
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Streptozotocin
Wistar rats
Insulin
Solid lipid nanoparticles
In vivo
Diabetes
Online Access:https://doi.org/10.1038/s41598-025-05137-3
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https://doi.org/10.1038/s41598-025-05137-3

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