Systemic Antifolate Chemotherapy Does Not Select for Fluconazole-Resistant <i>Candida</i>: A Multicenter Clinical Study

Systemic Antifolate Chemotherapy Does Not Select for Fluconazole-Resistant <i>Candida</i>: A Multicenter Clinical Study

Previous studies have demonstrated that <i>Candida</i> spp. isolates exposed in vitro to the folic acid antagonist methotrexate may develop multidrug cross-resistance to azole antifungals. The aim of this study was to determine whether systemic therapy with antineoplastic antifolates—pem...

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Main Authors: Dawid Żyrek, Joanna Nowicka, Magdalena Pajączkowska, Mariola Paściak, Katarzyna Machnik, Tomasz Werner, Zygmunt Konieczny, Piotr Jędrzejczak, Dominika Raźniewska, Gabriela Fijałkowska, Michał Piątek, Barbara Radecka, Kinga Żyrek, Elżbieta Woźniak-Grygiel, Iwona Dzieńdziora-Urbińska
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pathogens
Subjects:
cross-resistance
drug-induced resistance
antifolates
pemetrexed
methotrexate
<i>Candida</i>
Online Access:https://www.mdpi.com/2076-0817/14/6/574
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