Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration
Obesity is a civilization disease representing a global health problem. Excessive body weight significantly reduces the quality of life. It is also associated with the leading causes of death, including type 2 diabetes mellitus, cardiovascular diseases, and numerous types of cancer. The mainstay of...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/5527107 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556486096584704 |
|---|---|
| author | Jakub Poloczek Wojciech Kazura Ewa Kwaśnicka Janusz Gumprecht Jerzy Jochem Dominika Stygar |
| author_facet | Jakub Poloczek Wojciech Kazura Ewa Kwaśnicka Janusz Gumprecht Jerzy Jochem Dominika Stygar |
| author_sort | Jakub Poloczek |
| collection | DOAJ |
| description | Obesity is a civilization disease representing a global health problem. Excessive body weight significantly reduces the quality of life. It is also associated with the leading causes of death, including type 2 diabetes mellitus, cardiovascular diseases, and numerous types of cancer. The mainstay of therapy is a dietary treatment. However, in morbidly obese patients, dietary treatment is often insufficient. In these patients, the most effective procedure is bariatric surgery, but it is still difficult to predict its outcome and metabolic changes. Hepatokines are proteins secreted by hepatocytes. Many of them, including fetuin-A, selenoprotein P, angiopoietin-like protein 6, and fibroblast growth factor 21, have been linked to metabolic dysfunctions. In this context, hepatokines may prove helpful. This review investigates the possible changes in hepatokine profiles after selected bariatric surgery protocols. In this regard, Roux-en-Y gastric bypass is the most studied type of surgery. The overall analysis of published research identified fetuin-A as a potential marker of metabolic alternations in patients after bariatric surgery. |
| format | Article |
| id | doaj-art-9a1ba53843e74ded93cb53aa267b46b8 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-9a1ba53843e74ded93cb53aa267b46b82025-02-03T05:45:19ZengWileyJournal of Diabetes Research2314-67452314-67532021-01-01202110.1155/2021/55271075527107Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 ConcentrationJakub Poloczek0Wojciech Kazura1Ewa Kwaśnicka2Janusz Gumprecht3Jerzy Jochem4Dominika Stygar5Department of Rehabilitation, 3rd Specialist Hospital in Rybnik, 44-200 Rybnik, PolandDoctoral School of Medical University of Silesia, Department of Physiology, Faculty of Medical Sciences in Zabrze, 41-808 Zabrze, PolandPediatric Ward, Municipal Hospital in Żory, 44-240 Żory, PolandDepartment of Internal Medicine, Diabetology, and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, PolandDepartment of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, PolandDepartment of Physiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Zabrze, PolandObesity is a civilization disease representing a global health problem. Excessive body weight significantly reduces the quality of life. It is also associated with the leading causes of death, including type 2 diabetes mellitus, cardiovascular diseases, and numerous types of cancer. The mainstay of therapy is a dietary treatment. However, in morbidly obese patients, dietary treatment is often insufficient. In these patients, the most effective procedure is bariatric surgery, but it is still difficult to predict its outcome and metabolic changes. Hepatokines are proteins secreted by hepatocytes. Many of them, including fetuin-A, selenoprotein P, angiopoietin-like protein 6, and fibroblast growth factor 21, have been linked to metabolic dysfunctions. In this context, hepatokines may prove helpful. This review investigates the possible changes in hepatokine profiles after selected bariatric surgery protocols. In this regard, Roux-en-Y gastric bypass is the most studied type of surgery. The overall analysis of published research identified fetuin-A as a potential marker of metabolic alternations in patients after bariatric surgery.http://dx.doi.org/10.1155/2021/5527107 |
| spellingShingle | Jakub Poloczek Wojciech Kazura Ewa Kwaśnicka Janusz Gumprecht Jerzy Jochem Dominika Stygar Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration Journal of Diabetes Research |
| title | Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration |
| title_full | Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration |
| title_fullStr | Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration |
| title_full_unstemmed | Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration |
| title_short | Effects of Bariatric Surgeries on Fetuin-A, Selenoprotein P, Angiopoietin-Like Protein 6, and Fibroblast Growth Factor 21 Concentration |
| title_sort | effects of bariatric surgeries on fetuin a selenoprotein p angiopoietin like protein 6 and fibroblast growth factor 21 concentration |
| url | http://dx.doi.org/10.1155/2021/5527107 |
| work_keys_str_mv | AT jakubpoloczek effectsofbariatricsurgeriesonfetuinaselenoproteinpangiopoietinlikeprotein6andfibroblastgrowthfactor21concentration AT wojciechkazura effectsofbariatricsurgeriesonfetuinaselenoproteinpangiopoietinlikeprotein6andfibroblastgrowthfactor21concentration AT ewakwasnicka effectsofbariatricsurgeriesonfetuinaselenoproteinpangiopoietinlikeprotein6andfibroblastgrowthfactor21concentration AT januszgumprecht effectsofbariatricsurgeriesonfetuinaselenoproteinpangiopoietinlikeprotein6andfibroblastgrowthfactor21concentration AT jerzyjochem effectsofbariatricsurgeriesonfetuinaselenoproteinpangiopoietinlikeprotein6andfibroblastgrowthfactor21concentration AT dominikastygar effectsofbariatricsurgeriesonfetuinaselenoproteinpangiopoietinlikeprotein6andfibroblastgrowthfactor21concentration |