A multicountry evaluation of the Xpert MTB/RIF assay for the diagnosis of intrathoracic tuberculosis in children using alternative specimens (nasopharyngeal aspirate and stool): A prospective cohort study conducted in Madagascar, Ivory Coast and Cameroon (TB KIDS project)

A multicountry evaluation of the Xpert MTB/RIF assay for the diagnosis of intrathoracic tuberculosis in children using alternative specimens (nasopharyngeal aspirate and stool): A prospective cohort study conducted in Madagascar, Ivory Coast and Cameroon (TB KIDS project)

Objectives: Tuberculosis (TB) diagnosis in children remains challenging due to the paucibacillary nature of specimens and the difficulty in obtaining suitable samples. The use of alternative samples like nasopharyngeal aspirate (NPA) and stools, alongside Xpert MTB/RIF testing, offers promising impr...

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Main Authors: Rindra Vatosoa Randremanana, Mathurin Tejiokem, Niaina Rakotosamimanana, Valérie Donkeng Donfack, Verlaine Bolyse Mbouchong, Mirella Randrianarisoa, Aina Harimanana, Jean Voisin Taguebue, Suzie Tetang Ndiang, Valère Itchy, Annick Robinson, Lovaniaina Ravelomanana, Mbola Rakotomahefa, Dina Ranoharison, Man-Koumba Soumahoro, Brigitte Gicquel, Raymond N'Guessan, Sara Eyangoh, Voahangy Rasolofo, Emery Flavien Akpafi, Marius Irie Bi Irie, Anabelle Bai-Orsot, Jaudel Francis Yuya Septoh, Serge Abogo, Mamy Serge Raherison, Andrianantenaina Rakotoson, Vaomalala Raharimanga, Patrice Piola, Paulo Ranaivomanana, Jean-Marc Collard, Gabrielle Prisca Emmylou Andrianah, Turibio Razafindranaivo, Reziky Tiandraza Mangahasimbola, Kathleen Victoir
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:International Journal of Infectious Diseases
Subjects:
Tuberculosis
Children
Diagnosis
Xpert MTB/RIF
Nasopharyngeal aspirate
Stools
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971224004417
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