A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration
Refractory hypothyroidism is caused by decreased gut absorption, increased metabolism, and poor compliance. Previous studies suggested that the weekly oral, suppository, or intramuscular administration of levothyroxine (LT4) is an effective treatment for refractory hypothyroidism. However, limited i...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/5986014 |
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| author | Yujiro Nakano Koshi Hashimoto Noriaki Ohkiba Hideyuki Okuma Isao Minami Hiromitsu Takahashi Yuji Tanaka Takanobu Yoshimoto Tetsuya Yamada |
| author_facet | Yujiro Nakano Koshi Hashimoto Noriaki Ohkiba Hideyuki Okuma Isao Minami Hiromitsu Takahashi Yuji Tanaka Takanobu Yoshimoto Tetsuya Yamada |
| author_sort | Yujiro Nakano |
| collection | DOAJ |
| description | Refractory hypothyroidism is caused by decreased gut absorption, increased metabolism, and poor compliance. Previous studies suggested that the weekly oral, suppository, or intramuscular administration of levothyroxine (LT4) is an effective treatment for refractory hypothyroidism. However, limited information is currently available on treatment involving the weekly intravenous administration of LT4. We managed a case of refractory hypothyroidism due to poor compliance, for which, by weekly intravenous LT4 administration, LT4 was intravenously administered weekly at a dose of 300 μg without any adverse effects such as acute ischemic heart diseases or liver dysfunction and effectively maintained the euthyroid status for 14 months. The weekly oral administration of LT4 (700 μg) was also safely performed and was as effective as its intravenous administration. We herein present precise clinical course of the present case including pharmacokinetic data during the weekly intravenous and oral administration of LT4 and discuss the safety and efficacy of the treatments. |
| format | Article |
| id | doaj-art-99fdd114328d4c82b33c6b5c79f6e18f |
| institution | OA Journals |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-99fdd114328d4c82b33c6b5c79f6e18f2025-08-20T02:20:16ZengWileyCase Reports in Endocrinology2090-65012090-651X2019-01-01201910.1155/2019/59860145986014A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine AdministrationYujiro Nakano0Koshi Hashimoto1Noriaki Ohkiba2Hideyuki Okuma3Isao Minami4Hiromitsu Takahashi5Yuji Tanaka6Takanobu Yoshimoto7Tetsuya Yamada8Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, 113-8510, JapanDepartment of Preemptive and Metabolism, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, 113-8510, JapanDepartment of Endocrinology and Metabolism, Kashiwa Municipal Hospital, 277-0825, JapanDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, 113-8510, JapanDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, 113-8510, JapanDepartment of Pharmacy, Medical Hospital of Tokyo Medical and Dental University, 113-8510, JapanDepartment of General Medicine, National Defense Medical College Hospital, 359-0042, JapanDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, 113-8510, JapanDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, 113-8510, JapanRefractory hypothyroidism is caused by decreased gut absorption, increased metabolism, and poor compliance. Previous studies suggested that the weekly oral, suppository, or intramuscular administration of levothyroxine (LT4) is an effective treatment for refractory hypothyroidism. However, limited information is currently available on treatment involving the weekly intravenous administration of LT4. We managed a case of refractory hypothyroidism due to poor compliance, for which, by weekly intravenous LT4 administration, LT4 was intravenously administered weekly at a dose of 300 μg without any adverse effects such as acute ischemic heart diseases or liver dysfunction and effectively maintained the euthyroid status for 14 months. The weekly oral administration of LT4 (700 μg) was also safely performed and was as effective as its intravenous administration. We herein present precise clinical course of the present case including pharmacokinetic data during the weekly intravenous and oral administration of LT4 and discuss the safety and efficacy of the treatments.http://dx.doi.org/10.1155/2019/5986014 |
| spellingShingle | Yujiro Nakano Koshi Hashimoto Noriaki Ohkiba Hideyuki Okuma Isao Minami Hiromitsu Takahashi Yuji Tanaka Takanobu Yoshimoto Tetsuya Yamada A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration Case Reports in Endocrinology |
| title | A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration |
| title_full | A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration |
| title_fullStr | A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration |
| title_full_unstemmed | A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration |
| title_short | A Case of Refractory Hypothyroidism due to Poor Compliance Treated with the Weekly Intravenous and Oral Levothyroxine Administration |
| title_sort | case of refractory hypothyroidism due to poor compliance treated with the weekly intravenous and oral levothyroxine administration |
| url | http://dx.doi.org/10.1155/2019/5986014 |
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