Genetic depletion of adipose-derived Isthmin-1 causes hepatic steatosis

Genetic depletion of adipose-derived Isthmin-1 causes hepatic steatosis

Objectives: Adipose tissue plays a critical role in obesity, as its dysfunction can impair lipid homeostasis and result in lipid overflow and ectopic lipid deposition in the liver. We previously demonstrated that Isthmin-1 (Ism1) regulates glucose uptake into the adipose tissue and suppresses hepati...

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Main Authors: Saranya C. Reghupaty, Laetitia Coassolo, Meng Zhao, Ramya Lakshmi Narasimhan, Aayan Patel, Jameel Lone, Ewa Bielczyk-Maczynska, Niels B. Danneskiold-Samsoee, Taylor Brown, Zewen Jiang, Veronica L. Li, Katrin J. Svensson
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular Metabolism
Subjects:
Adiposity
Metabolic-dysfunction associated steatotic liver disease (MASLD)
Metabolic-dysfunction associated steatohepatitis (MASH)
Isthmin-1 (Ism1)
Lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000791
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