Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis
BackgroundBreast cancer, particularly triple-negative (TNBC), is a leading malignancy with aggressive traits and high metastasis rates. Clinical trial is an important tool for optimizing therapeutic strategies in the evaluation of the safety and efficacy for TNBC. Our bibliometric study of TNBC clin...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1423924/full |
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| author | Qi Xu Xiaoyu Feng Siyuan Qin Yu Hong Rui Cui Jia Liang Zhuya Xiao Yuan Li |
| author_facet | Qi Xu Xiaoyu Feng Siyuan Qin Yu Hong Rui Cui Jia Liang Zhuya Xiao Yuan Li |
| author_sort | Qi Xu |
| collection | DOAJ |
| description | BackgroundBreast cancer, particularly triple-negative (TNBC), is a leading malignancy with aggressive traits and high metastasis rates. Clinical trial is an important tool for optimizing therapeutic strategies in the evaluation of the safety and efficacy for TNBC. Our bibliometric study of TNBC clinical trials aims to assess therapeutic strategies, identify trends, and explore advancements in treatment. We focus on mapping knowledge development, including key research entities and topics, and analyzing research trends and emerging methods. This analysis intends to inform future research, especially in personalized and precision medicine for TNBC.MethodsWe selected publications on clinical trials for the treatment of TNBC from 1997 to 2024 in the Web of Science Core Collection (WoSCC). After an initial screening, we downloaded key data including titles, publication years, authors, countries, institutional affiliations, journals, keywords, and abstracts, and saved them in BibTex format. We then conducted a bibliometric analysis using Bibliometrix in R and VOSviewer to illustrate the prospects, highlights, and trends of TNBC treatment options. Furthermore, to emphasize the hot topics in TNBC treatment strategies, we performed a bibliometric analysis of immunotherapy using the same approach.Results1907 publications were included, most of which were from China, Italy, and the United States. The number of annual publications has increased dramatically since 2010. The focus of TNBC clinical trial research has shifted from understanding the biology, such as breast cancer subtyping and genotyping, to novel therapeutic approaches. The major advancement in clinical trials is the switch from late-stage palliative treatment to early preoperative neoadjuvant therapy, as more TNBC cases are discovered at an early stage. Immunotherapy is also highlighted with additional alternatives for advanced or metastasized TNBC, such as targeted inhibitors with unusual mutation rates and antibody drug conjugates (ADC).ConclusionsThis investigation made it apparent how immunotherapy has recently made major advancements in TNBC treatment plans and how ADCs, or targeted therapies, are currently popular for TNBC. By identifying significant papers, comprehending trending topics, and collaborating across multiple disciplines, this study may accelerate research on TNBC therapy options. |
| format | Article |
| id | doaj-art-99c5fe5b96e046b0af8c82fb7bf4a80d |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-99c5fe5b96e046b0af8c82fb7bf4a80d2025-01-31T16:06:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-10-011410.3389/fonc.2024.14239241423924Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysisQi Xu0Xiaoyu Feng1Siyuan Qin2Yu Hong3Rui Cui4Jia Liang5Zhuya Xiao6Yuan Li7The Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaThe Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaThe Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaThe Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaThe Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaThe Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, ChinaBackgroundBreast cancer, particularly triple-negative (TNBC), is a leading malignancy with aggressive traits and high metastasis rates. Clinical trial is an important tool for optimizing therapeutic strategies in the evaluation of the safety and efficacy for TNBC. Our bibliometric study of TNBC clinical trials aims to assess therapeutic strategies, identify trends, and explore advancements in treatment. We focus on mapping knowledge development, including key research entities and topics, and analyzing research trends and emerging methods. This analysis intends to inform future research, especially in personalized and precision medicine for TNBC.MethodsWe selected publications on clinical trials for the treatment of TNBC from 1997 to 2024 in the Web of Science Core Collection (WoSCC). After an initial screening, we downloaded key data including titles, publication years, authors, countries, institutional affiliations, journals, keywords, and abstracts, and saved them in BibTex format. We then conducted a bibliometric analysis using Bibliometrix in R and VOSviewer to illustrate the prospects, highlights, and trends of TNBC treatment options. Furthermore, to emphasize the hot topics in TNBC treatment strategies, we performed a bibliometric analysis of immunotherapy using the same approach.Results1907 publications were included, most of which were from China, Italy, and the United States. The number of annual publications has increased dramatically since 2010. The focus of TNBC clinical trial research has shifted from understanding the biology, such as breast cancer subtyping and genotyping, to novel therapeutic approaches. The major advancement in clinical trials is the switch from late-stage palliative treatment to early preoperative neoadjuvant therapy, as more TNBC cases are discovered at an early stage. Immunotherapy is also highlighted with additional alternatives for advanced or metastasized TNBC, such as targeted inhibitors with unusual mutation rates and antibody drug conjugates (ADC).ConclusionsThis investigation made it apparent how immunotherapy has recently made major advancements in TNBC treatment plans and how ADCs, or targeted therapies, are currently popular for TNBC. By identifying significant papers, comprehending trending topics, and collaborating across multiple disciplines, this study may accelerate research on TNBC therapy options.https://www.frontiersin.org/articles/10.3389/fonc.2024.1423924/fullbibliometric analysisTNBCclinical trialneoadjuvant therapyantibody drug conjugatesimmunotherapy |
| spellingShingle | Qi Xu Xiaoyu Feng Siyuan Qin Yu Hong Rui Cui Jia Liang Zhuya Xiao Yuan Li Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis Frontiers in Oncology bibliometric analysis TNBC clinical trial neoadjuvant therapy antibody drug conjugates immunotherapy |
| title | Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis |
| title_full | Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis |
| title_fullStr | Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis |
| title_full_unstemmed | Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis |
| title_short | Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis |
| title_sort | research on therapeutic clinical trials including immunotherapy in triple negative breast cancer a bibliometric analysis |
| topic | bibliometric analysis TNBC clinical trial neoadjuvant therapy antibody drug conjugates immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1423924/full |
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