Comprehensive experimental study on the impact of size and geometry of 3D-printed devices on solid-phase extraction efficiency and reproducibility
Our study investigated the impact of 3D-printed sorbent device geometry on extraction of benzodiazepines (BZD). Utilizing additive manufacturing (AM), we created devices with varying shapes and sizes, including cylinders and volumetric lattices. The sorbent material was a suspension of C18-coated si...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Talanta Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266683192500013X |
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| author | Bartosz Marciniak Paweł Georgiev Dagmara Kroll Szymon Ulenberg Tomasz Bączek Mariusz Belka |
| author_facet | Bartosz Marciniak Paweł Georgiev Dagmara Kroll Szymon Ulenberg Tomasz Bączek Mariusz Belka |
| author_sort | Bartosz Marciniak |
| collection | DOAJ |
| description | Our study investigated the impact of 3D-printed sorbent device geometry on extraction of benzodiazepines (BZD). Utilizing additive manufacturing (AM), we created devices with varying shapes and sizes, including cylinders and volumetric lattices. The sorbent material was a suspension of C18-coated silica gel in a photocurable resin. Our findings revealed that device geometry significantly influenced extraction efficiency. Area, internal shape, and size all impacted BZD recovery. Volumetric lattices, particularly gyroid and x-cell shapes, outperformed cylinders. Larger devices generally led to higher absolute recovery, but standardization per unit area showed smaller devices to be more efficient. These results provide valuable insights for designing optimized sorbent devices, contributing to advancements in solid-phase extraction. |
| format | Article |
| id | doaj-art-99aff7c7c50e4f78bc92aaefefbff89a |
| institution | Kabale University |
| issn | 2666-8319 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Talanta Open |
| spelling | doaj-art-99aff7c7c50e4f78bc92aaefefbff89a2025-01-24T04:45:50ZengElsevierTalanta Open2666-83192025-08-0111100410Comprehensive experimental study on the impact of size and geometry of 3D-printed devices on solid-phase extraction efficiency and reproducibilityBartosz Marciniak0Paweł Georgiev1Dagmara Kroll2Szymon Ulenberg3Tomasz Bączek4Mariusz Belka5Department of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416, Gdańsk, PolandDepartment of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416, Gdańsk, PolandDepartment of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416, Gdańsk, PolandDepartment of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416, Gdańsk, PolandDepartment of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416, Gdańsk, Poland; Department of Nursing and Medical Rescue, Institute of Health Sciences, Pomeranian University in Słupsk, 76-200, Słupsk, PolandDepartment of Pharmaceutical Chemistry, Medical University of Gdańsk, J. Hallera 107, 80-416, Gdańsk, Poland; Corresponding authorOur study investigated the impact of 3D-printed sorbent device geometry on extraction of benzodiazepines (BZD). Utilizing additive manufacturing (AM), we created devices with varying shapes and sizes, including cylinders and volumetric lattices. The sorbent material was a suspension of C18-coated silica gel in a photocurable resin. Our findings revealed that device geometry significantly influenced extraction efficiency. Area, internal shape, and size all impacted BZD recovery. Volumetric lattices, particularly gyroid and x-cell shapes, outperformed cylinders. Larger devices generally led to higher absolute recovery, but standardization per unit area showed smaller devices to be more efficient. These results provide valuable insights for designing optimized sorbent devices, contributing to advancements in solid-phase extraction.http://www.sciencedirect.com/science/article/pii/S266683192500013X3D printingDigital light processingExtractionGeometrySizeShape |
| spellingShingle | Bartosz Marciniak Paweł Georgiev Dagmara Kroll Szymon Ulenberg Tomasz Bączek Mariusz Belka Comprehensive experimental study on the impact of size and geometry of 3D-printed devices on solid-phase extraction efficiency and reproducibility Talanta Open 3D printing Digital light processing Extraction Geometry Size Shape |
| title | Comprehensive experimental study on the impact of size and geometry of 3D-printed devices on solid-phase extraction efficiency and reproducibility |
| title_full | Comprehensive experimental study on the impact of size and geometry of 3D-printed devices on solid-phase extraction efficiency and reproducibility |
| title_fullStr | Comprehensive experimental study on the impact of size and geometry of 3D-printed devices on solid-phase extraction efficiency and reproducibility |
| title_full_unstemmed | Comprehensive experimental study on the impact of size and geometry of 3D-printed devices on solid-phase extraction efficiency and reproducibility |
| title_short | Comprehensive experimental study on the impact of size and geometry of 3D-printed devices on solid-phase extraction efficiency and reproducibility |
| title_sort | comprehensive experimental study on the impact of size and geometry of 3d printed devices on solid phase extraction efficiency and reproducibility |
| topic | 3D printing Digital light processing Extraction Geometry Size Shape |
| url | http://www.sciencedirect.com/science/article/pii/S266683192500013X |
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