The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer
Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenar...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/9797410 |
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| _version_ | 1832563649786413056 |
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| author | Nina Nayara Ferreira Martins Kelly Cristina da Silva Oliveira Amanda Braga Bona Marília de Arruda Cardoso Smith Geraldo Ishak Paulo Pimentel Assumpção Rommel Rodríguez Burbano Danielle Queiroz Calcagno |
| author_facet | Nina Nayara Ferreira Martins Kelly Cristina da Silva Oliveira Amanda Braga Bona Marília de Arruda Cardoso Smith Geraldo Ishak Paulo Pimentel Assumpção Rommel Rodríguez Burbano Danielle Queiroz Calcagno |
| author_sort | Nina Nayara Ferreira Martins |
| collection | DOAJ |
| description | Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several single-nucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors. |
| format | Article |
| id | doaj-art-99875e0f788d4dddbe96f7231b99abd7 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-99875e0f788d4dddbe96f7231b99abd72025-02-03T01:12:58ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/97974109797410The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract CancerNina Nayara Ferreira Martins0Kelly Cristina da Silva Oliveira1Amanda Braga Bona2Marília de Arruda Cardoso Smith3Geraldo Ishak4Paulo Pimentel Assumpção5Rommel Rodríguez Burbano6Danielle Queiroz Calcagno7Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, BrazilLaboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, BrazilUniversidade Federal de São Paulo, São Paulo, SP, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, BrazilLaboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, BrazilNúcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, PA, BrazilBiliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several single-nucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.http://dx.doi.org/10.1155/2016/9797410 |
| spellingShingle | Nina Nayara Ferreira Martins Kelly Cristina da Silva Oliveira Amanda Braga Bona Marília de Arruda Cardoso Smith Geraldo Ishak Paulo Pimentel Assumpção Rommel Rodríguez Burbano Danielle Queiroz Calcagno The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer Gastroenterology Research and Practice |
| title | The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer |
| title_full | The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer |
| title_fullStr | The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer |
| title_full_unstemmed | The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer |
| title_short | The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer |
| title_sort | emerging role of mirnas and their clinical implication in biliary tract cancer |
| url | http://dx.doi.org/10.1155/2016/9797410 |
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