Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration

Granulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor (G-CSFR) being expressed outside the hematopoietic system has revealed wider roles for G-CSF, particularly in tissue repair and regeneration. Ske...

Full description

Saved in:
Bibliographic Details
Main Authors: Craig R. Wright, Alister C. Ward, Aaron P. Russell
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2017/7517350
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832559846664175616
author Craig R. Wright
Alister C. Ward
Aaron P. Russell
author_facet Craig R. Wright
Alister C. Ward
Aaron P. Russell
author_sort Craig R. Wright
collection DOAJ
description Granulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor (G-CSFR) being expressed outside the hematopoietic system has revealed wider roles for G-CSF, particularly in tissue repair and regeneration. Skeletal muscle damage, including that following strenuous exercise, induces an elevation in plasma G-CSF, implicating it as a potential mediator of skeletal muscle repair. This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. This review focuses on the growing literature associated with G-CSF and G-CSFR in skeletal muscle under healthy and disease conditions and highlights the current controversies.
format Article
id doaj-art-9977f2b94bba41f88c9d7570dfa2cee5
institution Kabale University
issn 0962-9351
1466-1861
language English
publishDate 2017-01-01
publisher Wiley
record_format Article
series Mediators of Inflammation
spelling doaj-art-9977f2b94bba41f88c9d7570dfa2cee52025-02-03T01:29:09ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/75173507517350Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and RegenerationCraig R. Wright0Alister C. Ward1Aaron P. Russell2Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, AustraliaCentre for Molecular and Medical Research, School of Medicine, Deakin University, Waurn Ponds, VIC, AustraliaInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, AustraliaGranulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor (G-CSFR) being expressed outside the hematopoietic system has revealed wider roles for G-CSF, particularly in tissue repair and regeneration. Skeletal muscle damage, including that following strenuous exercise, induces an elevation in plasma G-CSF, implicating it as a potential mediator of skeletal muscle repair. This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. This review focuses on the growing literature associated with G-CSF and G-CSFR in skeletal muscle under healthy and disease conditions and highlights the current controversies.http://dx.doi.org/10.1155/2017/7517350
spellingShingle Craig R. Wright
Alister C. Ward
Aaron P. Russell
Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration
Mediators of Inflammation
title Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration
title_full Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration
title_fullStr Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration
title_full_unstemmed Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration
title_short Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration
title_sort granulocyte colony stimulating factor and its potential application for skeletal muscle repair and regeneration
url http://dx.doi.org/10.1155/2017/7517350
work_keys_str_mv AT craigrwright granulocytecolonystimulatingfactoranditspotentialapplicationforskeletalmusclerepairandregeneration
AT alistercward granulocytecolonystimulatingfactoranditspotentialapplicationforskeletalmusclerepairandregeneration
AT aaronprussell granulocytecolonystimulatingfactoranditspotentialapplicationforskeletalmusclerepairandregeneration