High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis
Purpose. To evaluate postoperative morbidity and long term oncologic and functional outcomes of high intensity focused ultrasound (HIFU) compared to brachytherapy for the treatment of localized prostate cancer. Material and Methods. Patients treated by brachytherapy were matched 1 : 1 with patients...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2015/350324 |
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| author | Fouad Aoun Ksenija Limani Alexandre Peltier Quentin Marcelis Marc Zanaty Alexandre Chamoun Marc Vanden Bossche Thierry Roumeguère Roland van Velthoven |
| author_facet | Fouad Aoun Ksenija Limani Alexandre Peltier Quentin Marcelis Marc Zanaty Alexandre Chamoun Marc Vanden Bossche Thierry Roumeguère Roland van Velthoven |
| author_sort | Fouad Aoun |
| collection | DOAJ |
| description | Purpose. To evaluate postoperative morbidity and long term oncologic and functional outcomes of high intensity focused ultrasound (HIFU) compared to brachytherapy for the treatment of localized prostate cancer. Material and Methods. Patients treated by brachytherapy were matched 1 : 1 with patients who underwent HIFU. Differences in postoperative complications across the two groups were assessed using Wilcoxon’s rank-sum or χ2 test. Kaplan-Meier curves, log-rank tests, and Cox regression models were constructed to assess differences in survival rates between the two groups. Results. Brachytherapy was significantly associated with lower voiding LUTS and less frequent acute urinary retention (p<0.05). Median oncologic follow-up was 83 months (13–123 months) in the HIFU cohort and 44 months (13–89 months) in the brachytherapy cohort. Median time to achieve PSA nadir was statistically shorter in the HIFU. Biochemical recurrence-free survival rate was significantly higher in the brachytherapy cohort compared to HIFU cohort (68.5% versus 53%, p<0.05). No statistically significant difference in metastasis-free, cancer specific, and overall survivals was observed between the two groups. Conclusion. HIFU and brachytherapy are safe with no significant difference in cancer specific survival on long term oncologic follow-up. Nonetheless, a randomized controlled trial is needed to confirm these results. |
| format | Article |
| id | doaj-art-993cd80ae05e4ef4af1f99703b7c0d66 |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-993cd80ae05e4ef4af1f99703b7c0d662025-02-03T05:46:09ZengWileyAdvances in Urology1687-63691687-63772015-01-01201510.1155/2015/350324350324High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair AnalysisFouad Aoun0Ksenija Limani1Alexandre Peltier2Quentin Marcelis3Marc Zanaty4Alexandre Chamoun5Marc Vanden Bossche6Thierry Roumeguère7Roland van Velthoven8Department of Urology, Jules Bordet Institute, Université Libre de Bruxelles, 1000 Brussels, BelgiumDepartment of Urology, Jules Bordet Institute, Université Libre de Bruxelles, 1000 Brussels, BelgiumDepartment of Urology, Jules Bordet Institute, Université Libre de Bruxelles, 1000 Brussels, BelgiumDepartment of Urology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Urology, Jules Bordet Institute, Université Libre de Bruxelles, 1000 Brussels, BelgiumDepartment of Urology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Urology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Urology, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Urology, Jules Bordet Institute, Université Libre de Bruxelles, 1000 Brussels, BelgiumPurpose. To evaluate postoperative morbidity and long term oncologic and functional outcomes of high intensity focused ultrasound (HIFU) compared to brachytherapy for the treatment of localized prostate cancer. Material and Methods. Patients treated by brachytherapy were matched 1 : 1 with patients who underwent HIFU. Differences in postoperative complications across the two groups were assessed using Wilcoxon’s rank-sum or χ2 test. Kaplan-Meier curves, log-rank tests, and Cox regression models were constructed to assess differences in survival rates between the two groups. Results. Brachytherapy was significantly associated with lower voiding LUTS and less frequent acute urinary retention (p<0.05). Median oncologic follow-up was 83 months (13–123 months) in the HIFU cohort and 44 months (13–89 months) in the brachytherapy cohort. Median time to achieve PSA nadir was statistically shorter in the HIFU. Biochemical recurrence-free survival rate was significantly higher in the brachytherapy cohort compared to HIFU cohort (68.5% versus 53%, p<0.05). No statistically significant difference in metastasis-free, cancer specific, and overall survivals was observed between the two groups. Conclusion. HIFU and brachytherapy are safe with no significant difference in cancer specific survival on long term oncologic follow-up. Nonetheless, a randomized controlled trial is needed to confirm these results.http://dx.doi.org/10.1155/2015/350324 |
| spellingShingle | Fouad Aoun Ksenija Limani Alexandre Peltier Quentin Marcelis Marc Zanaty Alexandre Chamoun Marc Vanden Bossche Thierry Roumeguère Roland van Velthoven High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis Advances in Urology |
| title | High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis |
| title_full | High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis |
| title_fullStr | High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis |
| title_full_unstemmed | High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis |
| title_short | High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis |
| title_sort | high intensity focused ultrasound versus brachytherapy for the treatment of localized prostate cancer a matched pair analysis |
| url | http://dx.doi.org/10.1155/2015/350324 |
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