Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations

Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations

Abstract Cluster randomised trials (CRTs) are important tools for evaluating the community-wide effect of malaria interventions. During the design stage, CRT sample sizes need to be inflated to account for the cluster heterogeneity in measured outcomes. The coefficient of variation (k), a measure of...

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Main Authors: Joseph Biggs, Joseph D. Challenger, Dominic Dee, Eldo Elobolobo, Carlos Chaccour, Francisco Saute, Sarah G. Staedke, Sibo Vilakati, Jade Benjamin Chung, Michelle S. Hsiang, Edgard Diniba Dabira, Annette Erhart, Umberto D’Alessandro, Rupam Tripura, Thomas J. Peto, Lorenz Von Seidlein, Mavuto Mukaka, Jacklin Mosha, Natacha Protopopoff, Manfred Accrombessi, Richard Hayes, Thomas S. Churcher, Jackie Cook
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61502-w
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https://doi.org/10.1038/s41467-025-61502-w

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