Exploring Novel Y140F/H Mutant Fungal CYP51 Inhibitors: A Molecular Docking and Dynamics Study on Thiophene Compounds

Exploring Novel Y140F/H Mutant Fungal CYP51 Inhibitors: A Molecular Docking and Dynamics Study on Thiophene Compounds

Background: Invasive fungal infections (IFIs) pose a significant risk specifically to the health of immunocompromised individuals, leading to a substantial number of deaths annually. Therapeutic options for IFIs are limited compared to bacterial infections, with only three classes of antifungal medi...

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Bibliographic Details
Main Authors: Abdulrahim A. Alzain, Alaa Edris, Rua M. Mukhtar, Hagar M. Mohamed, Malek Abdullah Marzoqi Aldowimar, Ali A. Alqarni, Gamal A. Mohamed, Sabrin R. M. Ibrahim
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-06-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
cyp51
drug discovery
fungal infections
health and well-being
molecular docking
molecular dynamics
thiophene
Online Access:https://journals.lww.com/10.4103/jpbs.jpbs_404_25
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https://journals.lww.com/10.4103/jpbs.jpbs_404_25

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