A Consecutive Genome Engineering Method Reveals a New Phenotype and Regulation of Glucose and Glycerol Utilization in Clostridium Pasteurianum

A Consecutive Genome Engineering Method Reveals a New Phenotype and Regulation of Glucose and Glycerol Utilization in Clostridium Pasteurianum

ABSTRACT Clostridium pasteurianum is a microorganism for production of 1,3‐propanediol (1,3‐PDO) and butanol, but suffers from lacking genetic tools for metabolic engineering to improve product titers. Furthermore, previous studies of C. pasteurianum have mainly focused on single genomic modificatio...

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Main Authors: Tom Nguyen, Luca W. G. Meleski, Minu P. Belavatta, Sivasubramanian Gurumoorthi, Chijian Zhang, Anna‐Lena Heins, An‐Ping Zeng
Format: Article
Language:English
Published: Wiley-VCH 2025-01-01
Series:Engineering in Life Sciences
Subjects:
Clostridium pasteurianum
consecutive genome engineering
CRISPR‐Cas
metabolic engineering
substrate utilization
Online Access:https://doi.org/10.1002/elsc.202400026
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https://doi.org/10.1002/elsc.202400026

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