Associations between handedness and brain functional connectivity patterns in children
Abstract Handedness develops early in life, but the structural and functional brain connectivity patterns associated with it remains unknown. Here we investigate associations between handedness and the asymmetry of brain connectivity in 9- to 10-years old children from the Adolescent Brain Cognitive...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46690-1 |
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| author | Dardo Tomasi Nora D. Volkow |
| author_facet | Dardo Tomasi Nora D. Volkow |
| author_sort | Dardo Tomasi |
| collection | DOAJ |
| description | Abstract Handedness develops early in life, but the structural and functional brain connectivity patterns associated with it remains unknown. Here we investigate associations between handedness and the asymmetry of brain connectivity in 9- to 10-years old children from the Adolescent Brain Cognitive Development (ABCD) study. Compared to right-handers, left-handers had increased global functional connectivity density in the left-hand motor area and decreased it in the right-hand motor area. A connectivity-based index of handedness provided a sharper differentiation between right- and left-handers. The laterality of hand-motor connectivity varied as a function of handedness in unimodal sensorimotor cortices, heteromodal areas, and cerebellum (P < 0.001) and reproduced across all regions of interest in Discovery and Replication subsamples. Here we show a strong association between handedness and the laterality of the functional connectivity patterns in the absence of differences in structural connectivity, brain morphometrics, and cortical myelin between left, right, and mixed handed children. |
| format | Article |
| id | doaj-art-98ecc5b57d1747e8a1005b038ba3bdd5 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-98ecc5b57d1747e8a1005b038ba3bdd52025-02-02T12:31:05ZengNature PortfolioNature Communications2041-17232024-03-0115111210.1038/s41467-024-46690-1Associations between handedness and brain functional connectivity patterns in childrenDardo Tomasi0Nora D. Volkow1National Institute on Alcohol Abuse and AlcoholismNational Institute on Alcohol Abuse and AlcoholismAbstract Handedness develops early in life, but the structural and functional brain connectivity patterns associated with it remains unknown. Here we investigate associations between handedness and the asymmetry of brain connectivity in 9- to 10-years old children from the Adolescent Brain Cognitive Development (ABCD) study. Compared to right-handers, left-handers had increased global functional connectivity density in the left-hand motor area and decreased it in the right-hand motor area. A connectivity-based index of handedness provided a sharper differentiation between right- and left-handers. The laterality of hand-motor connectivity varied as a function of handedness in unimodal sensorimotor cortices, heteromodal areas, and cerebellum (P < 0.001) and reproduced across all regions of interest in Discovery and Replication subsamples. Here we show a strong association between handedness and the laterality of the functional connectivity patterns in the absence of differences in structural connectivity, brain morphometrics, and cortical myelin between left, right, and mixed handed children.https://doi.org/10.1038/s41467-024-46690-1 |
| spellingShingle | Dardo Tomasi Nora D. Volkow Associations between handedness and brain functional connectivity patterns in children Nature Communications |
| title | Associations between handedness and brain functional connectivity patterns in children |
| title_full | Associations between handedness and brain functional connectivity patterns in children |
| title_fullStr | Associations between handedness and brain functional connectivity patterns in children |
| title_full_unstemmed | Associations between handedness and brain functional connectivity patterns in children |
| title_short | Associations between handedness and brain functional connectivity patterns in children |
| title_sort | associations between handedness and brain functional connectivity patterns in children |
| url | https://doi.org/10.1038/s41467-024-46690-1 |
| work_keys_str_mv | AT dardotomasi associationsbetweenhandednessandbrainfunctionalconnectivitypatternsinchildren AT noradvolkow associationsbetweenhandednessandbrainfunctionalconnectivitypatternsinchildren |