IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing of HSCs in response to hematopoietic stress and aging

IL-33/ST2 signaling in ILC2s drives exhaustion and myeloid skewing of HSCs in response to hematopoietic stress and aging

Summary: Inflammatory cues affect hematopoietic stem cell (HSC) homeostasis and drive proliferation and myeloid skewing of HSCs. The HSC niche in the bone marrow (BM) is populated by a variety of stromal and immune cells that sense and respond to cellular stress. We investigated how BM-resident type...

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Bibliographic Details
Main Authors: Pascal Naef, Carla A. Jaeger-Ruckstuhl, Noah Schnüriger, Stefan Forster, Inês Monteiro, Daniel Brigger, Alexander Eggel, Kai Kessenbrock, Carsten Riether, Adrian F. Ochsenbein
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Immune response
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422500639X
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