Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae

Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae

Abstract The rise of Klebsiella pneumoniae resistant to last‐resort antimicrobials poses an urgent threat to global health. The ramR‐ramA regulatory system critically influences drug resistance by regulating the AcrAB‐TolC efflux pump, which also plays a crucial role in the pathogenicity of K. pneum...

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Bibliographic Details
Main Authors: Wei Yu, Peiyao Jia, Xiaobing Chu, Shengjie Li, Xinmiao Jia, Ying Zhu, Xiaoyu Liu, Yingchun Xu, Qiwen Yang
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:iMetaOmics
Subjects:
AcrAB‐TolC efflux pump
eravacycline resistance
immune activation
Klebsiella pneumoniae
lipid A modification
ramR
Online Access:https://doi.org/10.1002/imo2.39
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