The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I
Autoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). Screening for antinuclear antibodies (ANA) is one of the diagnostic tests, which is usually performed if a person is suspected to have a systemic autoimmune disease. Ant...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/718201 |
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| author | Maaike Dirckx Marco W. J. Schreurs Marissa de Mos Dirk L. Stronks Frank J. P. M. Huygen |
| author_facet | Maaike Dirckx Marco W. J. Schreurs Marissa de Mos Dirk L. Stronks Frank J. P. M. Huygen |
| author_sort | Maaike Dirckx |
| collection | DOAJ |
| description | Autoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). Screening for antinuclear antibodies (ANA) is one of the diagnostic tests, which is usually performed if a person is suspected to have a systemic autoimmune disease. Antineuronal antibodies are autoantibodies directed against antigens in the central and/or peripheral nervous system. The aim of this study was to compare the prevalence of these antibodies in CRPS patients with the normal values of those antibodies in the healthy population.
Twenty seven (33%) of the 82 CRPS patients of whom serum was available showed a positive ANA test. This prevalence is significantly higher than in the general population. Six patients (7.3%) showed a positive result for typical antineuronal antibodies. This proportion, however, does not deviate from that in the general population. Our findings suggest that autoantibodies may be associated with the pathophysiology of CRPS, at least in a subset of patients. Further research is needed into defining this subset and into the role of autoantibodies in the pathogenesis of CRPS. |
| format | Article |
| id | doaj-art-98d59ac38eb84d4ab752e789e0199b4f |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-98d59ac38eb84d4ab752e789e0199b4f2025-02-03T01:03:44ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/718201718201The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type IMaaike Dirckx0Marco W. J. Schreurs1Marissa de Mos2Dirk L. Stronks3Frank J. P. M. Huygen4Center for Pain Medicine, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, NetherlandsDepartment of Immunology, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, NetherlandsCenter for Pain Medicine, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, NetherlandsCenter for Pain Medicine, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, NetherlandsCenter for Pain Medicine, Erasmus MC, University Medical Center, Postbus 2040, 3000 CA Rotterdam, NetherlandsAutoimmunity has been suggested as one of the pathophysiologic mechanisms that may underlie complex regional pain syndrome (CRPS). Screening for antinuclear antibodies (ANA) is one of the diagnostic tests, which is usually performed if a person is suspected to have a systemic autoimmune disease. Antineuronal antibodies are autoantibodies directed against antigens in the central and/or peripheral nervous system. The aim of this study was to compare the prevalence of these antibodies in CRPS patients with the normal values of those antibodies in the healthy population. Twenty seven (33%) of the 82 CRPS patients of whom serum was available showed a positive ANA test. This prevalence is significantly higher than in the general population. Six patients (7.3%) showed a positive result for typical antineuronal antibodies. This proportion, however, does not deviate from that in the general population. Our findings suggest that autoantibodies may be associated with the pathophysiology of CRPS, at least in a subset of patients. Further research is needed into defining this subset and into the role of autoantibodies in the pathogenesis of CRPS.http://dx.doi.org/10.1155/2015/718201 |
| spellingShingle | Maaike Dirckx Marco W. J. Schreurs Marissa de Mos Dirk L. Stronks Frank J. P. M. Huygen The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I Mediators of Inflammation |
| title | The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I |
| title_full | The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I |
| title_fullStr | The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I |
| title_full_unstemmed | The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I |
| title_short | The Prevalence of Autoantibodies in Complex Regional Pain Syndrome Type I |
| title_sort | prevalence of autoantibodies in complex regional pain syndrome type i |
| url | http://dx.doi.org/10.1155/2015/718201 |
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