TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection...

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Main Authors: Glen M Chew, Tsuyoshi Fujita, Gabriela M Webb, Benjamin J Burwitz, Helen L Wu, Jason S Reed, Katherine B Hammond, Kiera L Clayton, Naoto Ishii, Mohamed Abdel-Mohsen, Teri Liegler, Brooks I Mitchell, Frederick M Hecht, Mario Ostrowski, Cecilia M Shikuma, Scott G Hansen, Mark Maurer, Alan J Korman, Steven G Deeks, Jonah B Sacha, Lishomwa C Ndhlovu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005349&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005349&type=printable

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