Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma
Abstract Objective With the wide use of CT scan in clinical practice, more lung cancer was diagnosed in resectable stage. Pathological examination and genetic testing have become a routine procedure for lung adenocarcinoma following radical resection. This study analyzed special pathological compone...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-025-03680-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585652622852096 |
|---|---|
| author | Ji’an Zou Wei Han Yan Hu Chao Zeng Jina Li Weixuan Lei Jieming Cao Quanming Fei Mengqi Shao Junqi Yi Zeyu Cheng Li Wang Fang Wu Wenliang Liu |
| author_facet | Ji’an Zou Wei Han Yan Hu Chao Zeng Jina Li Weixuan Lei Jieming Cao Quanming Fei Mengqi Shao Junqi Yi Zeyu Cheng Li Wang Fang Wu Wenliang Liu |
| author_sort | Ji’an Zou |
| collection | DOAJ |
| description | Abstract Objective With the wide use of CT scan in clinical practice, more lung cancer was diagnosed in resectable stage. Pathological examination and genetic testing have become a routine procedure for lung adenocarcinoma following radical resection. This study analyzed special pathological components and gene mutations to explore their relationship with clinical characteristics and overall survival. Methods Clinical, pathological, and gene mutation data from 1,118 patients were collected. All patients underwent surgery at the Department of Thoracic Surgery, the Second Xiangya Hospital of Central South University. Patients were grouped based on pathological components and gene mutations. Differences in clinical features and overall survival were analyzed as well. Results Patients with mucinous, neuroendocrine, and poor-differentiated components were presented with more prognostic risk factors, including pleural invasion, carcinothrombosis, STAS, and advanced stages, along with varying frequencies of gene mutations. These factors significantly shortened overall survival. ALK and KRAS mutations were also associated with risk factors such as solid nodules, pleural invasion, STAS, and later stages. However, a significant reduction in overall survival was observed only in patients with the KRAS mutation. Relationship between gene mutations and pathological components still requires further investigation. Conclusion Special pathological components (mucinous, neuroendocrine, and poor-differentiated) and gene mutations had an influence on biological behavior of tumors, resulting in different clinical characteristics and prognosis. |
| format | Article |
| id | doaj-art-98b964e59f1a4d9e80c194731e7d166f |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-98b964e59f1a4d9e80c194731e7d166f2025-01-26T12:36:31ZengBMCWorld Journal of Surgical Oncology1477-78192025-01-0123111210.1186/s12957-025-03680-xGene mutation, clinical characteristics and pathology in resectable lung adenocarcinomaJi’an Zou0Wei Han1Yan Hu2Chao Zeng3Jina Li4Weixuan Lei5Jieming Cao6Quanming Fei7Mengqi Shao8Junqi Yi9Zeyu Cheng10Li Wang11Fang Wu12Wenliang Liu13Department of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityDepartment of Oncology, The Second Xiangya Hospital, Central South UniversityDepartment of Thoracic Surgery, The Second Xiangya Hospital, Central South UniversityAbstract Objective With the wide use of CT scan in clinical practice, more lung cancer was diagnosed in resectable stage. Pathological examination and genetic testing have become a routine procedure for lung adenocarcinoma following radical resection. This study analyzed special pathological components and gene mutations to explore their relationship with clinical characteristics and overall survival. Methods Clinical, pathological, and gene mutation data from 1,118 patients were collected. All patients underwent surgery at the Department of Thoracic Surgery, the Second Xiangya Hospital of Central South University. Patients were grouped based on pathological components and gene mutations. Differences in clinical features and overall survival were analyzed as well. Results Patients with mucinous, neuroendocrine, and poor-differentiated components were presented with more prognostic risk factors, including pleural invasion, carcinothrombosis, STAS, and advanced stages, along with varying frequencies of gene mutations. These factors significantly shortened overall survival. ALK and KRAS mutations were also associated with risk factors such as solid nodules, pleural invasion, STAS, and later stages. However, a significant reduction in overall survival was observed only in patients with the KRAS mutation. Relationship between gene mutations and pathological components still requires further investigation. Conclusion Special pathological components (mucinous, neuroendocrine, and poor-differentiated) and gene mutations had an influence on biological behavior of tumors, resulting in different clinical characteristics and prognosis.https://doi.org/10.1186/s12957-025-03680-xLung adenocarcinomaGene mutationPathologyComputed topographySurgery |
| spellingShingle | Ji’an Zou Wei Han Yan Hu Chao Zeng Jina Li Weixuan Lei Jieming Cao Quanming Fei Mengqi Shao Junqi Yi Zeyu Cheng Li Wang Fang Wu Wenliang Liu Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma World Journal of Surgical Oncology Lung adenocarcinoma Gene mutation Pathology Computed topography Surgery |
| title | Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma |
| title_full | Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma |
| title_fullStr | Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma |
| title_full_unstemmed | Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma |
| title_short | Gene mutation, clinical characteristics and pathology in resectable lung adenocarcinoma |
| title_sort | gene mutation clinical characteristics and pathology in resectable lung adenocarcinoma |
| topic | Lung adenocarcinoma Gene mutation Pathology Computed topography Surgery |
| url | https://doi.org/10.1186/s12957-025-03680-x |
| work_keys_str_mv | AT jianzou genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT weihan genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT yanhu genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT chaozeng genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT jinali genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT weixuanlei genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT jiemingcao genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT quanmingfei genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT mengqishao genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT junqiyi genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT zeyucheng genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT liwang genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT fangwu genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma AT wenliangliu genemutationclinicalcharacteristicsandpathologyinresectablelungadenocarcinoma |