Homeobox protein B6 and homeobox protein B8 control immune-cancer cell interactions in pancreatic cancer

Homeobox protein B6 and homeobox protein B8 control immune-cancer cell interactions in pancreatic cancer

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer lacking effective drugs and therefore new treatment targets are needed. In this study, we define the role of homeobox protein B6 (HOXB6) and HOXB8 in controlling pancreatic cancer tumorigenesis and immune response. Transcriptomic an...

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Main Authors: Ludivine Bertonnier-Brouty, Sara Bsharat, Kavya Achanta, Jonas Andersson, Thanya Pranomphon, Tania Singh, Tuomas Kaprio, Jaana Hagström, Caj Haglund, Hanna Seppänen, Rashmi B. Prasad, Isabella Artner
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Molecular Biomedicine
Subjects:
Homeobox protein B6 (HOXB6)
Homeobox protein B8 (HOXB8)
Fetal pancreas
Pancreatic cancer
Pancreatic ductal adenocarcinoma
Tumor-associated-macrophages
Online Access:https://doi.org/10.1186/s43556-025-00292-5
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https://doi.org/10.1186/s43556-025-00292-5

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