The association between plasma betaine level and brain structural changes in schizophrenia

The association between plasma betaine level and brain structural changes in schizophrenia

Abstract Previous studies on metabolic profiling have shown decreased plasma levels of betaine in schizophrenia. Betaine serves as a substrate of betaine-homocysteine methyltransferase, which converts homocysteine to methionine. A decrease in betaine may lead to the elevation of homocysteine and an...

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Main Authors: Favour Omileke, Tempei Ikegame, Shimon Tonsho, Shunsuke Mori, Eimu Shoji, Masahiro Kiyota, Takuto Minami, Eureka Kumagai, Tatsuro Asai, Kenji Kirihara, Shinsuke Koike, Seiichiro Jinde, Kouhei Kamiya, Osamu Abe, Kiyoto Kasai, Naohiro Okada
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-025-00657-3
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https://doi.org/10.1038/s41537-025-00657-3

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