In vitro degradation of β‐amyloid fibrils by microbial keratinase

In vitro degradation of β‐amyloid fibrils by microbial keratinase

Abstract Introduction Amyloid fibrils are misfolded, protease‐resistant forms of normal proteins. They are infectious such as prions or noninfectious such as β‐amyloid (Aβ) fibrils causing Alzheimer's disease (AD). Prions and amyloids are structurally similar, possessing cross β‐pleated sheet‐l...

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Main Authors: Debananda S. Ningthoujam, Saikat Mukherjee, Laishram Jaya Devi, Elangbam Shanta Singh, Keishing Tamreihao, Rakhi Khunjamayum, Sumita Banerjee, Debashis Mukhopadhyay
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Actinomycete
Keratinase
β‐amyloid fibrils
Ker 1
In vitro degradation
Online Access:https://doi.org/10.1016/j.trci.2019.03.003
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https://doi.org/10.1016/j.trci.2019.03.003

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