BioBone – A prospective, blinded, multicenter validation study of the CD8 + terminal differentiated effector memory cells (CD8 + TEMRA cells) as prognostic biomarker for disturbed fracture healing – study design

BioBone – A prospective, blinded, multicenter validation study of the CD8 + terminal differentiated effector memory cells (CD8 + TEMRA cells) as prognostic biomarker for disturbed fracture healing – study design

Abstract Aims The BioBone consortium aims to validate circulating CD8 + TEMRA cells as a prognostic biomarker for predicting impaired fracture healing outcomes in a prospective, blinded, multicenter clinical study. The primary performance parameters are the pre-operative identification of at least 3...

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Main Authors: Simon Reinke, Anja Maria Bauer, Michael Dahne, Georg Duda, Denis Gümbel, Christian Kleber, Georg Matziolis, Sven Märdian, Georg Osterhoff, Carsten Perka, Michael J. Raschke, Sebastian Rohe, Klaus-Dieter Schaser, Philipp Schwabe, Frederik Maximilian Schäfer, Richard Stange, Maik Stiehler, Ulrich Stöckle, Hans-Dieter Volk, Stefan Weber, Sven Geißler, the BioBone Author Consortium
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Long bone fracture
Impaired healing
CD8 + TEMRA
Prognostic biomarker
Online Access:https://doi.org/10.1186/s13018-025-05987-7
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