A Diagnostic Approach to Hemochromatosis
In the present clinical review, a diagnostic approach to hemochromatosis is discussed from the perspective of two clinicians with extensive experience in this area. The introduction of genetic testing and large-scale population screening studies have broadened our understanding of the clinical expre...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2006/934098 |
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| _version_ | 1832563649115324416 |
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| author | Anthony S Tavill Paul C Adams |
| author_facet | Anthony S Tavill Paul C Adams |
| author_sort | Anthony S Tavill |
| collection | DOAJ |
| description | In the present clinical review, a diagnostic approach to hemochromatosis is discussed from the perspective of two clinicians with extensive experience in this area. The introduction of genetic testing and large-scale population screening studies have broadened our understanding of the clinical expression of disease and the utility of biochemical iron tests for the detection of disease and for the assessment of disease severity. Liver biopsy has become more of a prognostic test than a diagnostic test. The authors offer a stepwise, diagnostic algorithm based on current evidence-based data, that they regard as most cost-effective. An early diagnosis can lead to phlebotomy therapy to prevent the development of cirrhosis. |
| format | Article |
| id | doaj-art-97bc9f6a6a594773b2a717dcbea591e5 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-97bc9f6a6a594773b2a717dcbea591e52025-02-03T01:13:03ZengWileyCanadian Journal of Gastroenterology0835-79002006-01-0120853554010.1155/2006/934098A Diagnostic Approach to HemochromatosisAnthony S Tavill0Paul C Adams1Case Western Reserve School of Medicine and Cleveland Clinic Foundation, Cleveland, Ohio, USAUniversity Hospital, University of Western Ontario, London, Ontario, CanadaIn the present clinical review, a diagnostic approach to hemochromatosis is discussed from the perspective of two clinicians with extensive experience in this area. The introduction of genetic testing and large-scale population screening studies have broadened our understanding of the clinical expression of disease and the utility of biochemical iron tests for the detection of disease and for the assessment of disease severity. Liver biopsy has become more of a prognostic test than a diagnostic test. The authors offer a stepwise, diagnostic algorithm based on current evidence-based data, that they regard as most cost-effective. An early diagnosis can lead to phlebotomy therapy to prevent the development of cirrhosis.http://dx.doi.org/10.1155/2006/934098 |
| spellingShingle | Anthony S Tavill Paul C Adams A Diagnostic Approach to Hemochromatosis Canadian Journal of Gastroenterology |
| title | A Diagnostic Approach to Hemochromatosis |
| title_full | A Diagnostic Approach to Hemochromatosis |
| title_fullStr | A Diagnostic Approach to Hemochromatosis |
| title_full_unstemmed | A Diagnostic Approach to Hemochromatosis |
| title_short | A Diagnostic Approach to Hemochromatosis |
| title_sort | diagnostic approach to hemochromatosis |
| url | http://dx.doi.org/10.1155/2006/934098 |
| work_keys_str_mv | AT anthonystavill adiagnosticapproachtohemochromatosis AT paulcadams adiagnosticapproachtohemochromatosis AT anthonystavill diagnosticapproachtohemochromatosis AT paulcadams diagnosticapproachtohemochromatosis |