Adipokines and Hepatic Insulin Resistance
Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factor...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/170532 |
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| _version_ | 1832562892661063680 |
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| author | Yu Li Lin Ding Waseem Hassan Daoud Abdelkader Jing Shang |
| author_facet | Yu Li Lin Ding Waseem Hassan Daoud Abdelkader Jing Shang |
| author_sort | Yu Li |
| collection | DOAJ |
| description | Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factors might provide a molecular link between increased adiposity and impaired insulin sensitivity. Since hepatic insulin resistance plays the key role in the whole body insulin resistance, clarification of the regulatory processes about hepatic insulin resistance by adipokines in rodents and human would seem essential in order to understand the mechanism of type 2 diabetes and for developing novel therapeutic strategies to treat it. |
| format | Article |
| id | doaj-art-97b1e35180fb45e2ab5cc3b951018cfd |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-97b1e35180fb45e2ab5cc3b951018cfd2025-02-03T01:21:36ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/170532170532Adipokines and Hepatic Insulin ResistanceYu Li0Lin Ding1Waseem Hassan2Daoud Abdelkader3Jing Shang4National Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaNational Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaNational Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaNational Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaNational Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaObesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factors might provide a molecular link between increased adiposity and impaired insulin sensitivity. Since hepatic insulin resistance plays the key role in the whole body insulin resistance, clarification of the regulatory processes about hepatic insulin resistance by adipokines in rodents and human would seem essential in order to understand the mechanism of type 2 diabetes and for developing novel therapeutic strategies to treat it.http://dx.doi.org/10.1155/2013/170532 |
| spellingShingle | Yu Li Lin Ding Waseem Hassan Daoud Abdelkader Jing Shang Adipokines and Hepatic Insulin Resistance Journal of Diabetes Research |
| title | Adipokines and Hepatic Insulin Resistance |
| title_full | Adipokines and Hepatic Insulin Resistance |
| title_fullStr | Adipokines and Hepatic Insulin Resistance |
| title_full_unstemmed | Adipokines and Hepatic Insulin Resistance |
| title_short | Adipokines and Hepatic Insulin Resistance |
| title_sort | adipokines and hepatic insulin resistance |
| url | http://dx.doi.org/10.1155/2013/170532 |
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