In-silico analysis unveiling the role of cancer stem cells in immunotherapy resistance of immune checkpoint-high pancreatic adenocarcinoma

In-silico analysis unveiling the role of cancer stem cells in immunotherapy resistance of immune checkpoint-high pancreatic adenocarcinoma

Abstract Although immune checkpoint (IC) inhibition is a major treatment modality in cancer-immunotherapy, multiple cancers show low response. Our in-silico exploration by mining cancer datasets using R2, available clinical trial data, and Kaplan–Meier analysis from GEPIA depicted that unlike low-re...

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Bibliographic Details
Main Authors: Udit Basak, Sumon Mukherjee, Sourio Chakraborty, Gaurisankar Sa, Shubhra Ghosh Dastidar, Tanya Das
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Adenocarcinoma
Cancer stem cells
Immune checkpoint
Immunotherapy
In-silico study
Pancreatic
Online Access:https://doi.org/10.1038/s41598-025-93924-3
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https://doi.org/10.1038/s41598-025-93924-3

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