Lossless single-molecule counting to absolute quantify proteoforms

Lossless single-molecule counting to absolute quantify proteoforms

Abstract A novel immunoassay, termed Protein Interaction Coupling (PICO), is introduced to deliver clear, reference-free quantification of proteoforms - precise quantification. PICO employs a compartmentalized, homogeneous single-molecule assay with lossless and sensitive signal generation, capable...

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Main Authors: Tobias Gross, Tobias Hundertmark, Villő Csiszár, András Attila Sulyok, Nina Gross, Maike Breiden, Niklas Kitschen, Uritza von Groll, Christoph Niemöller, Pablo Sánchez-Martín, Anne Heine, Jens Göpfert, Tamás Szórádi, Philipp Lübbert, Peter Koltay, Peter Porschewski, Roland Zengerle, Csaba Jeney
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-91053-5
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