Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10
Exemestane (EXE) is an irreversible steroidal aromatase inhibitor mainly used as an adjuvant endocrine therapy for postmenopausal women suffering from breast cancer. Besides inhibiting aromatase activity, EXE has multiple biological functions, such as antiproliferation, anti-inflammatory, and antiox...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3072745 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567323055095808 |
|---|---|
| author | Ya-Hui Wang Rong-Kun Li Ying Fu Jun Li Xiao-Mei Yang Yan-Li Zhang Lei Zhu Qin Yang Jian-Ren Gu Xin Xing Zhi-Gang Zhang |
| author_facet | Ya-Hui Wang Rong-Kun Li Ying Fu Jun Li Xiao-Mei Yang Yan-Li Zhang Lei Zhu Qin Yang Jian-Ren Gu Xin Xing Zhi-Gang Zhang |
| author_sort | Ya-Hui Wang |
| collection | DOAJ |
| description | Exemestane (EXE) is an irreversible steroidal aromatase inhibitor mainly used as an adjuvant endocrine therapy for postmenopausal women suffering from breast cancer. Besides inhibiting aromatase activity, EXE has multiple biological functions, such as antiproliferation, anti-inflammatory, and antioxidant activities which are all involved in hepatic fibrosis. Therefore, we investigated the role of EXE during the progress of hepatic fibrosis. The effect of EXE on liver injury and fibrosis were assessed in two hepatic fibrosis rat models, which were induced by either carbon tetrachloride (CCl4) or bile duct ligation (BDL). The influence of EXE treatment on activation and proliferation of primary rat hepatic stellate cells (HSCs) was observed in vitro. The results showed that EXE attenuated the liver fibrosis by decreasing the collagen deposition and α-SMA expression in vivo and inhibited the activation and proliferation of primary rat HSCs in vitro. Additionally, EXE promoted the secretion of antifibrotic and anti-inflammatory cytokine IL-10 in vivo and in HSC-T6 culture media. In conclusion, our findings reveal a new function of EXE on hepatic fibrosis and prompted its latent application in liver fibrotic-related disease. |
| format | Article |
| id | doaj-art-978766c41b2a4c84ae660cad480d0032 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-978766c41b2a4c84ae660cad480d00322025-02-03T01:01:49ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/30727453072745Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10Ya-Hui Wang0Rong-Kun Li1Ying Fu2Jun Li3Xiao-Mei Yang4Yan-Li Zhang5Lei Zhu6Qin Yang7Jian-Ren Gu8Xin Xing9Zhi-Gang Zhang10Shanghai Medical College of Fudan University, Shanghai 200032, ChinaDepartment of Oncology, Huai’an First People’s Hospital, Nanjing Medical University, Huai’an 223300, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaShanghai Medical College of Fudan University, Shanghai 200032, ChinaDepartment of Obstetrics and Gynecology, Fengxian Hospital, Shanghai 201499, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, ChinaExemestane (EXE) is an irreversible steroidal aromatase inhibitor mainly used as an adjuvant endocrine therapy for postmenopausal women suffering from breast cancer. Besides inhibiting aromatase activity, EXE has multiple biological functions, such as antiproliferation, anti-inflammatory, and antioxidant activities which are all involved in hepatic fibrosis. Therefore, we investigated the role of EXE during the progress of hepatic fibrosis. The effect of EXE on liver injury and fibrosis were assessed in two hepatic fibrosis rat models, which were induced by either carbon tetrachloride (CCl4) or bile duct ligation (BDL). The influence of EXE treatment on activation and proliferation of primary rat hepatic stellate cells (HSCs) was observed in vitro. The results showed that EXE attenuated the liver fibrosis by decreasing the collagen deposition and α-SMA expression in vivo and inhibited the activation and proliferation of primary rat HSCs in vitro. Additionally, EXE promoted the secretion of antifibrotic and anti-inflammatory cytokine IL-10 in vivo and in HSC-T6 culture media. In conclusion, our findings reveal a new function of EXE on hepatic fibrosis and prompted its latent application in liver fibrotic-related disease.http://dx.doi.org/10.1155/2017/3072745 |
| spellingShingle | Ya-Hui Wang Rong-Kun Li Ying Fu Jun Li Xiao-Mei Yang Yan-Li Zhang Lei Zhu Qin Yang Jian-Ren Gu Xin Xing Zhi-Gang Zhang Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 Journal of Immunology Research |
| title | Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 |
| title_full | Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 |
| title_fullStr | Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 |
| title_full_unstemmed | Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 |
| title_short | Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10 |
| title_sort | exemestane attenuates hepatic fibrosis in rats by inhibiting activation of hepatic stellate cells and promoting the secretion of interleukin 10 |
| url | http://dx.doi.org/10.1155/2017/3072745 |
| work_keys_str_mv | AT yahuiwang exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT rongkunli exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT yingfu exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT junli exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT xiaomeiyang exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT yanlizhang exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT leizhu exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT qinyang exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT jianrengu exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT xinxing exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 AT zhigangzhang exemestaneattenuateshepaticfibrosisinratsbyinhibitingactivationofhepaticstellatecellsandpromotingthesecretionofinterleukin10 |