Status of Vitamin D in Childhood-onset Systemic Lupus Erythematosus and its Relation with the Disease Activity
Objective: This study aims to determine the vitamin D level in childhood-onset systemic lupus erythematosus (cSLE) and its association with disease activity both before and after vitamin D supplementation. Methods: This prospective study was done over 18 months (Feb 2019–July 2020) in a tertiary car...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_373_24 |
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| Summary: | Objective:
This study aims to determine the vitamin D level in childhood-onset systemic lupus erythematosus (cSLE) and its association with disease activity both before and after vitamin D supplementation.
Methods:
This prospective study was done over 18 months (Feb 2019–July 2020) in a tertiary care center in Eastern India on 52 cases and 52 age-and sex-matched controls. Baseline vitamin D level and Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) were assessed and compared at 3 months follow-up after vitamin D supplementation in those having serum vitamin D <20 ng/ml and SLEDAI <12 at baseline.
Results:
cSLE cases had a significantly lower prevalence (P = 0.011) of vitamin D sufficiency than the controls. Vitamin D supplementation was given to all cases with serum vitamin D levels <20 ng/ml. Follow-up serum vitamin D was found to be significantly inversely correlated with respective SLEDAI-2K scores (r = -0.594, P < 0.001).
Conclusions:
Vitamin D insufficiency and deficiency are highly prevalent among children with SLE. Following supplementation with oral vitamin D, there is significant improvement in disease activity in these children. Therefore, assessment of vitamin D levels should be routinely done in cSLE patients and its supplementation may be considered in those with low levels to reduce morbidity. |
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| ISSN: | 2589-8302 2589-8310 |