HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS
Background: Vaginal atrophy has occurred in three quarters of post-menopausal women. The exclusive source of post-menopausal sex hormones is dehydroepiandrosterone (DHEA). Purpose: Observe the impact of orally administered DHEA in the vagina of a rat (Rattus norvegicus) post- bilateral ovariectomy....
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Universitas Airlangga
2024-07-01
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| Series: | Journal of Vocational Health Studies |
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| Online Access: | https://e-journal.unair.ac.id/JVHS/article/view/43780 |
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| author | Lis Widodo Peni Pilar Menara Falah Yudha Nurdian |
| author_facet | Lis Widodo Peni Pilar Menara Falah Yudha Nurdian |
| author_sort | Lis Widodo Peni |
| collection | DOAJ |
| description | Background: Vaginal atrophy has occurred in three quarters of post-menopausal women. The exclusive source of post-menopausal sex hormones is dehydroepiandrosterone (DHEA). Purpose: Observe the impact of orally administered DHEA in the vagina of a rat (Rattus norvegicus) post- bilateral ovariectomy. Method: This experiment utilized 36 wistar rats aged 10 - 12 weeks with a body weight of 180 - 200 grams. The rats were randomly divided into two groups with an equal number of members. The control group was orally administered glycerin via gavage at a dose of 1 mL per day, while the treatment group received 7.2 mg of DHEA dissolved in glycerin, also administered orally via gavage at a daily dose of up to 1 mL. Both groups were maintained for 42 consecutive days. Finally, a histomorphology examination was conducted on the vaginal tissues of the sacrificed rats. Result: The mean of epithelial and smooth muscle thickness of the treatment group was significantly higher than that of the control group (p-value < 0.05). Besides, the number of blood vessels were also significantly higher in the treated group (p-value < 0.05). Conclusion: Administering DHEA orally via gavage enhances epithelial and smooth muscle tissue thickness, and augments the number of blood vessels in the vagina of wistar rats after bilateral ovariectomy. |
| format | Article |
| id | doaj-art-97772f02a3d14f438fe84de24d818438 |
| institution | Kabale University |
| issn | 2580-7161 2580-717X |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Journal of Vocational Health Studies |
| spelling | doaj-art-97772f02a3d14f438fe84de24d8184382025-02-02T06:19:52ZengUniversitas AirlanggaJournal of Vocational Health Studies2580-71612580-717X2024-07-0181131910.20473/jvhs.V8.I1.2024.13-1941862HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATSLis Widodo Peni0Pilar Menara Falah1https://orcid.org/0000-0001-7574-4918Yudha Nurdian2https://orcid.org/0000-0001-7088-3425Anti-Aging Post-Graduate Program, Udayana UniversityDepartment of Basic Dental Sciences, Faculty of Dentistry, University of JemberDepartment of Basic Medical Sciences, Faculty of Medicine, University of JemberBackground: Vaginal atrophy has occurred in three quarters of post-menopausal women. The exclusive source of post-menopausal sex hormones is dehydroepiandrosterone (DHEA). Purpose: Observe the impact of orally administered DHEA in the vagina of a rat (Rattus norvegicus) post- bilateral ovariectomy. Method: This experiment utilized 36 wistar rats aged 10 - 12 weeks with a body weight of 180 - 200 grams. The rats were randomly divided into two groups with an equal number of members. The control group was orally administered glycerin via gavage at a dose of 1 mL per day, while the treatment group received 7.2 mg of DHEA dissolved in glycerin, also administered orally via gavage at a daily dose of up to 1 mL. Both groups were maintained for 42 consecutive days. Finally, a histomorphology examination was conducted on the vaginal tissues of the sacrificed rats. Result: The mean of epithelial and smooth muscle thickness of the treatment group was significantly higher than that of the control group (p-value < 0.05). Besides, the number of blood vessels were also significantly higher in the treated group (p-value < 0.05). Conclusion: Administering DHEA orally via gavage enhances epithelial and smooth muscle tissue thickness, and augments the number of blood vessels in the vagina of wistar rats after bilateral ovariectomy.https://e-journal.unair.ac.id/JVHS/article/view/43780enhancementdehydroepiandrosteroneovariectomyvaginal wall |
| spellingShingle | Lis Widodo Peni Pilar Menara Falah Yudha Nurdian HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS Journal of Vocational Health Studies enhancement dehydroepiandrosterone ovariectomy vaginal wall |
| title | HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS |
| title_full | HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS |
| title_fullStr | HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS |
| title_full_unstemmed | HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS |
| title_short | HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS |
| title_sort | histomorphological enhancement of the vaginal wall in dehydroepiandrosterone treated post ovariectomized wistar rats |
| topic | enhancement dehydroepiandrosterone ovariectomy vaginal wall |
| url | https://e-journal.unair.ac.id/JVHS/article/view/43780 |
| work_keys_str_mv | AT liswidodopeni histomorphologicalenhancementofthevaginalwallindehydroepiandrosteronetreatedpostovariectomizedwistarrats AT pilarmenarafalah histomorphologicalenhancementofthevaginalwallindehydroepiandrosteronetreatedpostovariectomizedwistarrats AT yudhanurdian histomorphologicalenhancementofthevaginalwallindehydroepiandrosteronetreatedpostovariectomizedwistarrats |