Intercellular communication between hepatic stellate cells and myofibroblasts mediated by osteopontin and FGF18 promotes liver fibrosis

Intercellular communication between hepatic stellate cells and myofibroblasts mediated by osteopontin and FGF18 promotes liver fibrosis

Summary: Hepatic stellate cells (HSCs) play a central role in the development of liver fibrosis. We previously showed that fibroblast growth factor 18 (FGF18) promotes liver fibrosis by increasing HSC proliferation. However, the underlying mechanisms remain incompletely understood. Here, we showed t...

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Bibliographic Details
Main Authors: Takao Seki, Sachiko Komazawa-Sakon, Takashi Nishina, Tetuo Mikami, Hideo Yagita, Katsuhide Okunishi, Minoru Tanaka, Yuichi Tsuchiya, Hiroyasu Nakano
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Cell biology
Fibrosis
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225011939
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