Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji
Abstract Background The burden of Aedes aegypti-transmitted viruses such as dengue, chikungunya, and Zika are increasing globally, fueled by urbanization and climate change, with some of the highest current rates of transmission in Asia. Local factors in the built environment have the potential to e...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12879-024-10315-1 |
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| author | Joelle I. Rosser John J. Openshaw Audrie Lin Ruzka R. Taruc Autiko Tela Nursehang Tamodding Nurul Pausi Emelia Abdullah Murni Amiruddin Esra Buyukcangaz S. Fiona Barker Amelia Turagabeci Ansariadi Karin Leder Isra Wahid on behalf of the RISE Consortium |
| author_facet | Joelle I. Rosser John J. Openshaw Audrie Lin Ruzka R. Taruc Autiko Tela Nursehang Tamodding Nurul Pausi Emelia Abdullah Murni Amiruddin Esra Buyukcangaz S. Fiona Barker Amelia Turagabeci Ansariadi Karin Leder Isra Wahid on behalf of the RISE Consortium |
| author_sort | Joelle I. Rosser |
| collection | DOAJ |
| description | Abstract Background The burden of Aedes aegypti-transmitted viruses such as dengue, chikungunya, and Zika are increasing globally, fueled by urbanization and climate change, with some of the highest current rates of transmission in Asia. Local factors in the built environment have the potential to exacerbate or mitigate transmission. Methods In 24 informal urban settlements in Makassar, Indonesia and Suva, Fiji, we tested children under 5 years old for evidence of prior infection with dengue, chikungunya, and Zika viruses by IgG serology. We used a catalytic model using seroprevalence and mean age to estimate annual incidence of dengue in each country. We also conducted detailed questionnaires to evaluate environmental risk factors for a positive serology result. Dengue risk factors were evaluated for children by univariate and multivariable logistic regression accounting for settlement as a fixed effect. Trash and flooding were additionally evaluated as dengue risk factors at the settlement level by univariate linear regression. Results In Fiji and Indonesia respectively, 46% and 33% of children under 5 years old were seropositive for dengue, 3% and 3% for chikungunya, and 9% and 2% for Zika. In Indonesia, children living in a household where trash is routinely collected and removed were significantly less likely to be dengue seropositive in both unadjusted and adjusted models [adjusted model: OR 0.3 (95% CI: 0.1–0.8)]. In Indonesia, settlements with a higher proportion of households reporting flooding also had lower dengue rates (slope = 0.44; p-value: <0.05). Conclusions Household trash collection and community flood management are important targets for interventions to mitigate the increasing risk of Aedes aegypti-transmitted viruses. |
| format | Article |
| id | doaj-art-9724f650cba84aeab4c1bbb2ff8b4313 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-9724f650cba84aeab4c1bbb2ff8b43132025-01-19T12:11:40ZengBMCBMC Infectious Diseases1471-23342025-01-0125111110.1186/s12879-024-10315-1Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and FijiJoelle I. Rosser0John J. Openshaw1Audrie Lin2Ruzka R. Taruc3Autiko Tela4Nursehang Tamodding5Nurul Pausi Emelia Abdullah6Murni Amiruddin7Esra Buyukcangaz8S. Fiona Barker9Amelia Turagabeci10Ansariadi11Karin Leder12Isra Wahid13on behalf of the RISE ConsortiumDivision of Infectious Diseases, School of Medicine, Stanford UniversityDivision of Infectious Diseases, School of Medicine, Stanford UniversityDepartment of Microbiology and Environmental Toxicology, University of California Santa CruzMonash Sustainable Development Institute, Monash UniversityMonash Sustainable Development Institute, Monash UniversityFaculty of Medicine, Center for Zoonotic and Emerging Diseases HUMRC, Universitas HasanuddinFaculty of Medicine, Center for Zoonotic and Emerging Diseases HUMRC, Universitas HasanuddinFaculty of Medicine, Center for Zoonotic and Emerging Diseases HUMRC, Universitas HasanuddinDivision of Pediatric Infectious Diseases, School of Medicine, Stanford UniversitySchool of Public Health and Preventive Medicine, Monash UniversityFiji Institute of Pacific Health Research, College of Medicine, Nursing and Health Sciences, Fiji National UniversityFaculty of Public Health, Hasanuddin UniversitySchool of Public Health and Preventive Medicine, Monash UniversityFaculty of Medicine, Center for Zoonotic and Emerging Diseases HUMRC, Universitas HasanuddinAbstract Background The burden of Aedes aegypti-transmitted viruses such as dengue, chikungunya, and Zika are increasing globally, fueled by urbanization and climate change, with some of the highest current rates of transmission in Asia. Local factors in the built environment have the potential to exacerbate or mitigate transmission. Methods In 24 informal urban settlements in Makassar, Indonesia and Suva, Fiji, we tested children under 5 years old for evidence of prior infection with dengue, chikungunya, and Zika viruses by IgG serology. We used a catalytic model using seroprevalence and mean age to estimate annual incidence of dengue in each country. We also conducted detailed questionnaires to evaluate environmental risk factors for a positive serology result. Dengue risk factors were evaluated for children by univariate and multivariable logistic regression accounting for settlement as a fixed effect. Trash and flooding were additionally evaluated as dengue risk factors at the settlement level by univariate linear regression. Results In Fiji and Indonesia respectively, 46% and 33% of children under 5 years old were seropositive for dengue, 3% and 3% for chikungunya, and 9% and 2% for Zika. In Indonesia, children living in a household where trash is routinely collected and removed were significantly less likely to be dengue seropositive in both unadjusted and adjusted models [adjusted model: OR 0.3 (95% CI: 0.1–0.8)]. In Indonesia, settlements with a higher proportion of households reporting flooding also had lower dengue rates (slope = 0.44; p-value: <0.05). Conclusions Household trash collection and community flood management are important targets for interventions to mitigate the increasing risk of Aedes aegypti-transmitted viruses.https://doi.org/10.1186/s12879-024-10315-1AedesTrashWasteArbovirusesVector borne diseasesDengue |
| spellingShingle | Joelle I. Rosser John J. Openshaw Audrie Lin Ruzka R. Taruc Autiko Tela Nursehang Tamodding Nurul Pausi Emelia Abdullah Murni Amiruddin Esra Buyukcangaz S. Fiona Barker Amelia Turagabeci Ansariadi Karin Leder Isra Wahid on behalf of the RISE Consortium Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji BMC Infectious Diseases Aedes Trash Waste Arboviruses Vector borne diseases Dengue |
| title | Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji |
| title_full | Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji |
| title_fullStr | Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji |
| title_full_unstemmed | Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji |
| title_short | Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji |
| title_sort | seroprevalence incidence estimates and environmental risk factors for dengue chikungunya and zika infection amongst children living in informal urban settlements in indonesia and fiji |
| topic | Aedes Trash Waste Arboviruses Vector borne diseases Dengue |
| url | https://doi.org/10.1186/s12879-024-10315-1 |
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