The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/5263974 |
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| author | Manuel Varas-Godoy Gregory Rice Sebastián E. Illanes |
| author_facet | Manuel Varas-Godoy Gregory Rice Sebastián E. Illanes |
| author_sort | Manuel Varas-Godoy |
| collection | DOAJ |
| description | Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer. |
| format | Article |
| id | doaj-art-96d4e74e0ede4da5b04164e3ae23c934 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-96d4e74e0ede4da5b04164e3ae23c9342025-02-03T01:00:50ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/52639745263974The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor MicroenvironmentManuel Varas-Godoy0Gregory Rice1Sebastián E. Illanes2Laboratory of Reproductive Biology, Center for Biomedical Research, Faculty of Medicine, Universidad de Los Andes, Santiago, ChileCentre for Clinical Diagnostics, Royal Brisbane and Women’s Hospital, University of Queensland Centre for Clinical Research, Brisbane, QLD, AustraliaLaboratory of Reproductive Biology, Center for Biomedical Research, Faculty of Medicine, Universidad de Los Andes, Santiago, ChileOvarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer.http://dx.doi.org/10.1155/2017/5263974 |
| spellingShingle | Manuel Varas-Godoy Gregory Rice Sebastián E. Illanes The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment Stem Cells International |
| title | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
| title_full | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
| title_fullStr | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
| title_full_unstemmed | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
| title_short | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
| title_sort | crosstalk between ovarian cancer stem cell niche and the tumor microenvironment |
| url | http://dx.doi.org/10.1155/2017/5263974 |
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