Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine
Immunosuppressants, particularly tacrolimus, can induce neurotoxicity in solid organ transplantation cases. A lower clinical threshold to switch from tacrolimus to another immunosuppressant agent has been a common approach to reverse this neurotoxicity. However, immunosuppressant switch may place th...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2014/250472 |
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| _version_ | 1832552793461751808 |
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| author | James A. Bourgeois Ana Hategan |
| author_facet | James A. Bourgeois Ana Hategan |
| author_sort | James A. Bourgeois |
| collection | DOAJ |
| description | Immunosuppressants, particularly tacrolimus, can induce neurotoxicity in solid organ transplantation cases. A lower clinical threshold to switch from tacrolimus to another immunosuppressant agent has been a common approach to reverse this neurotoxicity. However, immunosuppressant switch may place the graft at risk, and, in some cases, continuation of the same treatment protocol may be necessary. We report a case of immunosuppressant-associated neurotoxicity with prominent neuropsychiatric manifestation and describe psychiatric intervention with olanzapine that led to clinical improvement while continuing tacrolimus maintenance. |
| format | Article |
| id | doaj-art-96a617e4a9cb4081beda5562dae8ec2a |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-96a617e4a9cb4081beda5562dae8ec2a2025-02-03T05:57:48ZengWileyCase Reports in Psychiatry2090-682X2090-68382014-01-01201410.1155/2014/250472250472Immunosuppressant-Associated Neurotoxicity Responding to OlanzapineJames A. Bourgeois0Ana Hategan1Department of Psychiatry, Langley Porter Psychiatric Institute, Consultation-Liaison Service, University of California San Francisco Medical Center, 401 Parnassus Avenue, San Francisco, CA 94143, USADepartment of Psychiatry and Behavioural Neurosciences, Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, St. Joseph’s Healthcare Hamilton, 100 West 5th Street, Hamilton, ON, L8N 3K7, CanadaImmunosuppressants, particularly tacrolimus, can induce neurotoxicity in solid organ transplantation cases. A lower clinical threshold to switch from tacrolimus to another immunosuppressant agent has been a common approach to reverse this neurotoxicity. However, immunosuppressant switch may place the graft at risk, and, in some cases, continuation of the same treatment protocol may be necessary. We report a case of immunosuppressant-associated neurotoxicity with prominent neuropsychiatric manifestation and describe psychiatric intervention with olanzapine that led to clinical improvement while continuing tacrolimus maintenance.http://dx.doi.org/10.1155/2014/250472 |
| spellingShingle | James A. Bourgeois Ana Hategan Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine Case Reports in Psychiatry |
| title | Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine |
| title_full | Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine |
| title_fullStr | Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine |
| title_full_unstemmed | Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine |
| title_short | Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine |
| title_sort | immunosuppressant associated neurotoxicity responding to olanzapine |
| url | http://dx.doi.org/10.1155/2014/250472 |
| work_keys_str_mv | AT jamesabourgeois immunosuppressantassociatedneurotoxicityrespondingtoolanzapine AT anahategan immunosuppressantassociatedneurotoxicityrespondingtoolanzapine |