Prevalence of suicidal ideation, attempts and associated risk factors in oral cancer patients: a systematic review and meta-analysis
Abstract Background Oral cancer, including malignancies of the lip, and oral cavity, is associated with significant psychological distress, increasing the risk of suicidal ideation (SI) and suicide attempts (SA). Despite its severe morbidity and mortality, the prevalence of SI and SA and their assoc...
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2025-01-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-05511-7 |
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| author | Ganesh Bushi Mahalaqua Nazli Khatib Mahendra Pratap Singh Manisa Pattanayak Teena Vishwakarma Suhas Ballal Pooja Bansal Abhay M Gaidhane Balvir S. Tomar Ayash Ashraf M Ravi Kumar Ashish Singh Chauhan Sanjit Sah Edward Mawejje Muhammed Shabil |
| author_facet | Ganesh Bushi Mahalaqua Nazli Khatib Mahendra Pratap Singh Manisa Pattanayak Teena Vishwakarma Suhas Ballal Pooja Bansal Abhay M Gaidhane Balvir S. Tomar Ayash Ashraf M Ravi Kumar Ashish Singh Chauhan Sanjit Sah Edward Mawejje Muhammed Shabil |
| author_sort | Ganesh Bushi |
| collection | DOAJ |
| description | Abstract Background Oral cancer, including malignancies of the lip, and oral cavity, is associated with significant psychological distress, increasing the risk of suicidal ideation (SI) and suicide attempts (SA). Despite its severe morbidity and mortality, the prevalence of SI and SA and their associated risk factors remain unclear. This systematic review and meta-analysis aimed to quantify the prevalence of SI and SA among oral cancer patients and identify key psychosocial risk factors. Methods A comprehensive literature search was conducted across PubMed, Embase, and Web of Science databases, with an initial search on August 13, 2024, and an update on December 19, 2024. Observational studies reporting SI and SA prevalence in oral cancer patients were included. Study quality was assessed using a modified Newcastle-Ottawa Scale (NOS), and statistical analyses were performed using R version 4.4. Pooled prevalence rates were calculated using a random-effects model, heterogeneity was assessed with I² statistics, sensitivity analysis was performed using a leave-one-out approach, and publication bias was evaluated using Doi plots and LFK index values. Results From 5,145 articles, 13 studies from Taiwan, South Korea, Canada, Germany, and the United States, involving 899,765 participants, were included. The pooled prevalence of SI was 13.08% (95% CI, 7.41–22.03) with moderate heterogeneity (I² = 65%), while SA prevalence was 0.32% (95% CI, 0.1–0.7) with high heterogeneity (I² = 99%). Key risk factors included depression (OR = 42.83), dysphoria (OR = 8.06), prior cancer history (OR = 4.53), rural residence, and male gender. Conclusion This review revealed a substantial psychological impact faced by oral cancer patients, with notable prevalence rates of suicidal ideation and suicide attempts. Identifying major risk factors, such as depression and dysphoria, underscores the need for integrating tailored mental health interventions into routine oncological care. |
| format | Article |
| id | doaj-art-9682f43da46d47e0899f3a7d5eaa89be |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-9682f43da46d47e0899f3a7d5eaa89be2025-01-26T12:55:09ZengBMCBMC Oral Health1472-68312025-01-0125111010.1186/s12903-025-05511-7Prevalence of suicidal ideation, attempts and associated risk factors in oral cancer patients: a systematic review and meta-analysisGanesh Bushi0Mahalaqua Nazli Khatib1Mahendra Pratap Singh2Manisa Pattanayak3Teena Vishwakarma4Suhas Ballal5Pooja Bansal6Abhay M Gaidhane7Balvir S. Tomar8Ayash Ashraf9M Ravi Kumar10Ashish Singh Chauhan11Sanjit Sah12Edward Mawejje13Muhammed Shabil14School of Pharmaceutical Sciences, Lovely Professional UniversityDivision of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher EducationCenter for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha UniversityDepartment of Surgical Oncology, Graphic Era (Deemed to be University), Clement TownIES Institute of Pharmacy, IES UniversityDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University)Department of Allied Healthcare and Sciences, Vivekananda Global UniversityGlobal Health Academy, School of Epidemiology and Public Health, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher EducationInstitute of Pediatric Gastroenterology and Hepatology, NIMS UniversityChandigarh Pharmacy College, Chandigarh Group of CollegeDepartment of Chemistry, Raghu Engineering CollegeDivision of Research and Innovation, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal UniversityDepartment of Paediatrics, Dr. D. Y. Patil Medical College Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed-to-be-University)School of Public Health, Makerere University College of Health SciencesUniversity Center for Research and Development, Chandigarh UniversityAbstract Background Oral cancer, including malignancies of the lip, and oral cavity, is associated with significant psychological distress, increasing the risk of suicidal ideation (SI) and suicide attempts (SA). Despite its severe morbidity and mortality, the prevalence of SI and SA and their associated risk factors remain unclear. This systematic review and meta-analysis aimed to quantify the prevalence of SI and SA among oral cancer patients and identify key psychosocial risk factors. Methods A comprehensive literature search was conducted across PubMed, Embase, and Web of Science databases, with an initial search on August 13, 2024, and an update on December 19, 2024. Observational studies reporting SI and SA prevalence in oral cancer patients were included. Study quality was assessed using a modified Newcastle-Ottawa Scale (NOS), and statistical analyses were performed using R version 4.4. Pooled prevalence rates were calculated using a random-effects model, heterogeneity was assessed with I² statistics, sensitivity analysis was performed using a leave-one-out approach, and publication bias was evaluated using Doi plots and LFK index values. Results From 5,145 articles, 13 studies from Taiwan, South Korea, Canada, Germany, and the United States, involving 899,765 participants, were included. The pooled prevalence of SI was 13.08% (95% CI, 7.41–22.03) with moderate heterogeneity (I² = 65%), while SA prevalence was 0.32% (95% CI, 0.1–0.7) with high heterogeneity (I² = 99%). Key risk factors included depression (OR = 42.83), dysphoria (OR = 8.06), prior cancer history (OR = 4.53), rural residence, and male gender. Conclusion This review revealed a substantial psychological impact faced by oral cancer patients, with notable prevalence rates of suicidal ideation and suicide attempts. Identifying major risk factors, such as depression and dysphoria, underscores the need for integrating tailored mental health interventions into routine oncological care.https://doi.org/10.1186/s12903-025-05511-7Oral cancerSuicidal ideationSuicide attemptsMental healthSystematic reviewMeta-analysis |
| spellingShingle | Ganesh Bushi Mahalaqua Nazli Khatib Mahendra Pratap Singh Manisa Pattanayak Teena Vishwakarma Suhas Ballal Pooja Bansal Abhay M Gaidhane Balvir S. Tomar Ayash Ashraf M Ravi Kumar Ashish Singh Chauhan Sanjit Sah Edward Mawejje Muhammed Shabil Prevalence of suicidal ideation, attempts and associated risk factors in oral cancer patients: a systematic review and meta-analysis BMC Oral Health Oral cancer Suicidal ideation Suicide attempts Mental health Systematic review Meta-analysis |
| title | Prevalence of suicidal ideation, attempts and associated risk factors in oral cancer patients: a systematic review and meta-analysis |
| title_full | Prevalence of suicidal ideation, attempts and associated risk factors in oral cancer patients: a systematic review and meta-analysis |
| title_fullStr | Prevalence of suicidal ideation, attempts and associated risk factors in oral cancer patients: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of suicidal ideation, attempts and associated risk factors in oral cancer patients: a systematic review and meta-analysis |
| title_short | Prevalence of suicidal ideation, attempts and associated risk factors in oral cancer patients: a systematic review and meta-analysis |
| title_sort | prevalence of suicidal ideation attempts and associated risk factors in oral cancer patients a systematic review and meta analysis |
| topic | Oral cancer Suicidal ideation Suicide attempts Mental health Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12903-025-05511-7 |
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