The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge
BackgroundThis study aimed to evaluate the correlation between the metabolic score for insulin resistance (METS-IR) and myocardial ischemia based on myocardial perfusion imaging (MPI) and further examine whether non-alcoholic fatty liver disease (NAFLD) has a potential role in mediating these associ...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1592463/full |
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| author | Yu Tian Yu Tian Fan Sun Fan Sun Wenji Yu Wenji Yu Feifei Zhang Feifei Zhang Jianfeng Wang Jianfeng Wang Xiaoliang Shao Xiaoliang Shao Bao Liu Bao Liu Xiaoyu Yang Yongjun Chen Sijin Li Yuetao Wang Yuetao Wang |
| author_facet | Yu Tian Yu Tian Fan Sun Fan Sun Wenji Yu Wenji Yu Feifei Zhang Feifei Zhang Jianfeng Wang Jianfeng Wang Xiaoliang Shao Xiaoliang Shao Bao Liu Bao Liu Xiaoyu Yang Yongjun Chen Sijin Li Yuetao Wang Yuetao Wang |
| author_sort | Yu Tian |
| collection | DOAJ |
| description | BackgroundThis study aimed to evaluate the correlation between the metabolic score for insulin resistance (METS-IR) and myocardial ischemia based on myocardial perfusion imaging (MPI) and further examine whether non-alcoholic fatty liver disease (NAFLD) has a potential role in mediating these associations.MethodsThis retrospective study enrolled 1,242 patients with suspected coronary artery disease (CAD) who underwent single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) at the Third Affiliated Hospital of Soochow University from 1 January 2022 to 31 December 2024. The association between METS-IR and myocardial ischemia was analyzed using the logistic regression model. The mediating effect of NAFLD was evaluated through mediation analysis to explore the potential mechanism underlying the association between METS-IR and myocardial ischemia.ResultsThe final group of participants included 335 patients; 179 (53.4%) patients had myocardial ischemia. Overall, the mean age was 61.45 ± 10.20 years, 188 (56.1%) were men, and the mean body mass index was 24.69 ± 3.21 kg/m2. Mean METS-IR was 2.40 ± 0.22 (range, 1.79–3.80). The results of the single-factor analysis showed that a per-SD increase in METS-IR was independently associated with myocardial ischemia (OR, 3.92; 95% CI: 1.38-11.08; P =0.010). After adjusting for all interfering factors, METS-IR had no associations with myocardial ischemia. The results of the mediation analysis show that NAFLD is a complete mediator variable between MERSIR and myocardial ischemia.ConclusionThis study provides evidence for the relationship between METS-IR and myocardial ischemia and highlights the important mediating role of NAFLD in this relationship. |
| format | Article |
| id | doaj-art-967d30eb8e4641d2b871b00b11f9829e |
| institution | OA Journals |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-967d30eb8e4641d2b871b00b11f9829e2025-08-20T02:03:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-06-011610.3389/fendo.2025.15924631592463The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridgeYu Tian0Yu Tian1Fan Sun2Fan Sun3Wenji Yu4Wenji Yu5Feifei Zhang6Feifei Zhang7Jianfeng Wang8Jianfeng Wang9Xiaoliang Shao10Xiaoliang Shao11Bao Liu12Bao Liu13Xiaoyu Yang14Yongjun Chen15Sijin Li16Yuetao Wang17Yuetao Wang18Department of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, Jiangsu, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, Jiangsu, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, Jiangsu, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, Jiangsu, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, Jiangsu, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, Jiangsu, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaInstitute of Clinical Translation of Nuclear Medicine and Molecular Imaging, Soochow University, Changzhou, Jiangsu, ChinaBackgroundThis study aimed to evaluate the correlation between the metabolic score for insulin resistance (METS-IR) and myocardial ischemia based on myocardial perfusion imaging (MPI) and further examine whether non-alcoholic fatty liver disease (NAFLD) has a potential role in mediating these associations.MethodsThis retrospective study enrolled 1,242 patients with suspected coronary artery disease (CAD) who underwent single-photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) at the Third Affiliated Hospital of Soochow University from 1 January 2022 to 31 December 2024. The association between METS-IR and myocardial ischemia was analyzed using the logistic regression model. The mediating effect of NAFLD was evaluated through mediation analysis to explore the potential mechanism underlying the association between METS-IR and myocardial ischemia.ResultsThe final group of participants included 335 patients; 179 (53.4%) patients had myocardial ischemia. Overall, the mean age was 61.45 ± 10.20 years, 188 (56.1%) were men, and the mean body mass index was 24.69 ± 3.21 kg/m2. Mean METS-IR was 2.40 ± 0.22 (range, 1.79–3.80). The results of the single-factor analysis showed that a per-SD increase in METS-IR was independently associated with myocardial ischemia (OR, 3.92; 95% CI: 1.38-11.08; P =0.010). After adjusting for all interfering factors, METS-IR had no associations with myocardial ischemia. The results of the mediation analysis show that NAFLD is a complete mediator variable between MERSIR and myocardial ischemia.ConclusionThis study provides evidence for the relationship between METS-IR and myocardial ischemia and highlights the important mediating role of NAFLD in this relationship.https://www.frontiersin.org/articles/10.3389/fendo.2025.1592463/fullmetabolic score for insulin resistance (METS-IR)non-alcoholic fatty liver disease (NAFLD)myocardial ischemiamediating effectmyocardial perfusion imaging (MPI) |
| spellingShingle | Yu Tian Yu Tian Fan Sun Fan Sun Wenji Yu Wenji Yu Feifei Zhang Feifei Zhang Jianfeng Wang Jianfeng Wang Xiaoliang Shao Xiaoliang Shao Bao Liu Bao Liu Xiaoyu Yang Yongjun Chen Sijin Li Yuetao Wang Yuetao Wang The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge Frontiers in Endocrinology metabolic score for insulin resistance (METS-IR) non-alcoholic fatty liver disease (NAFLD) myocardial ischemia mediating effect myocardial perfusion imaging (MPI) |
| title | The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge |
| title_full | The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge |
| title_fullStr | The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge |
| title_full_unstemmed | The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge |
| title_short | The metabolic score for insulin resistance index is associated with myocardial ischemia, with non-alcoholic fatty liver disease serving as an important bridge |
| title_sort | metabolic score for insulin resistance index is associated with myocardial ischemia with non alcoholic fatty liver disease serving as an important bridge |
| topic | metabolic score for insulin resistance (METS-IR) non-alcoholic fatty liver disease (NAFLD) myocardial ischemia mediating effect myocardial perfusion imaging (MPI) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1592463/full |
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