Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential
Glucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and a promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, and satiety. We e...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750025000137 |
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| author | Tohada M. AL-Noshokaty Rehab Abdelhamid Nourhan M. Abdelmaksoud Aya Khaled Mariam Hossam Razan Ahmed Toka Saber Shahd Khaled Shereen Saeid Elshaer Ahmed I. Abulsoud |
| author_facet | Tohada M. AL-Noshokaty Rehab Abdelhamid Nourhan M. Abdelmaksoud Aya Khaled Mariam Hossam Razan Ahmed Toka Saber Shahd Khaled Shereen Saeid Elshaer Ahmed I. Abulsoud |
| author_sort | Tohada M. AL-Noshokaty |
| collection | DOAJ |
| description | Glucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and a promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, and satiety. We examine the compelling evidence supporting GLP-1 receptor agonists (GLP-1RAs) in managing type 2 diabetes (T2D), obesity, and other diseases. The intricate molecular mechanisms underlying GLP-1RAs are explored, including their interactions with pathways like extracellular signal-regulated kinase 1/2 (ERK1/2), activated protein kinase (AMPK), cyclic adenine monophosphate (cAMP), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC). Expanding our understanding, the review investigates the potential role of GLP-1 in cancers. Also, microribonucleic acid (RNA) (miRNAs), critical regulators of gene expression, are introduced as potential modulators of GLP-1 signaling. We delve into the link between miRNAs and T2D obesity and explore specific miRNA examples influencing GLP-1R function. Finally, the review explores the rationale for seeking alternatives to GLP-1RAs and highlights natural products with promising GLP-1 modulatory effects. |
| format | Article |
| id | doaj-art-9678b913a04d4040b08c53e23b9d0794 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-9678b913a04d4040b08c53e23b9d07942025-01-24T04:45:12ZengElsevierToxicology Reports2214-75002025-06-0114101895Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potentialTohada M. AL-Noshokaty0Rehab Abdelhamid1Nourhan M. Abdelmaksoud2Aya Khaled3Mariam Hossam4Razan Ahmed5Toka Saber6Shahd Khaled7Shereen Saeid Elshaer8Ahmed I. Abulsoud9Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Corresponding author.Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptDepartment of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, EgyptBiochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt; Faculty of Pharmacy, Heliopolis University, Cairo 11785, EgyptGlucagon (GCG) like peptide 1 (GLP-1) has emerged as a powerful player in regulating metabolism and a promising therapeutic target for various chronic diseases. This review delves into the physiological roles of GLP-1, exploring its impact on glucose homeostasis, insulin secretion, and satiety. We examine the compelling evidence supporting GLP-1 receptor agonists (GLP-1RAs) in managing type 2 diabetes (T2D), obesity, and other diseases. The intricate molecular mechanisms underlying GLP-1RAs are explored, including their interactions with pathways like extracellular signal-regulated kinase 1/2 (ERK1/2), activated protein kinase (AMPK), cyclic adenine monophosphate (cAMP), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC). Expanding our understanding, the review investigates the potential role of GLP-1 in cancers. Also, microribonucleic acid (RNA) (miRNAs), critical regulators of gene expression, are introduced as potential modulators of GLP-1 signaling. We delve into the link between miRNAs and T2D obesity and explore specific miRNA examples influencing GLP-1R function. Finally, the review explores the rationale for seeking alternatives to GLP-1RAs and highlights natural products with promising GLP-1 modulatory effects.http://www.sciencedirect.com/science/article/pii/S2214750025000137GLP-1GLP-1RAsDiabetesObesityCancermiRNAs |
| spellingShingle | Tohada M. AL-Noshokaty Rehab Abdelhamid Nourhan M. Abdelmaksoud Aya Khaled Mariam Hossam Razan Ahmed Toka Saber Shahd Khaled Shereen Saeid Elshaer Ahmed I. Abulsoud Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential Toxicology Reports GLP-1 GLP-1RAs Diabetes Obesity Cancer miRNAs |
| title | Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential |
| title_full | Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential |
| title_fullStr | Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential |
| title_full_unstemmed | Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential |
| title_short | Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential |
| title_sort | unlocking the multifaceted roles of glp 1 physiological functions and therapeutic potential |
| topic | GLP-1 GLP-1RAs Diabetes Obesity Cancer miRNAs |
| url | http://www.sciencedirect.com/science/article/pii/S2214750025000137 |
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