Serum Alkaline Phosphatase Levels in Pediatric Kikuchi‐Fujimoto Disease: A Retrospective Observational Analysis
ABSTRACT Aim Kikuchi‐Fujimoto disease (KFD) rarely affects pediatric patients and is characterized by prolonged fever and cervical lymphadenopathy. The diagnosis of KFD remains challenging and often requires an invasive biopsy. Low serum alkaline phosphatase levels have frequently been observed in p...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70129 |
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| author | Shintaro Fujiwara Yousuke Higuchi Junya Shimizu |
| author_facet | Shintaro Fujiwara Yousuke Higuchi Junya Shimizu |
| author_sort | Shintaro Fujiwara |
| collection | DOAJ |
| description | ABSTRACT Aim Kikuchi‐Fujimoto disease (KFD) rarely affects pediatric patients and is characterized by prolonged fever and cervical lymphadenopathy. The diagnosis of KFD remains challenging and often requires an invasive biopsy. Low serum alkaline phosphatase levels have frequently been observed in patients with KFD; however, the clinical significance of low serum alkaline phosphatase levels remains unclear. Methods This retrospective study included pediatric patients aged < 16 years who were pathologically or clinically diagnosed with KFD and infectious mononucleosis between April 2016 and March 2023. Serum alkaline phosphatase levels were analyzed employing age‐ and sex‐specific reference intervals. Clinical and laboratory data were evaluated to determine their association with serum alkaline phosphatase levels. Results Thirty patients with KFD and 23 patients with infectious mononucleosis were included in the study. Seventeen patients with KFD (56.7%) had serum alkaline phosphatase levels below the 2.5th percentile of the age‐ and sex‐specific reference intervals. Serum alkaline phosphatase levels were significantly lower in patients with KFD than in those with infectious mononucleosis. Clinical and other laboratory findings were not significantly different between patients with KFD with or without a decline in serum alkaline phosphatase levels. Conclusion A decrease in serum alkaline phosphatase levels, particularly when assessed as a percentage of age‐ and sex‐specific reference intervals, may be a valuable and noninvasive supportive feature of KFD in pediatric patients. |
| format | Article |
| id | doaj-art-964df9496e304126bd468090755e93de |
| institution | Kabale University |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-964df9496e304126bd468090755e93de2025-02-06T07:50:38ZengWileyImmunity, Inflammation and Disease2050-45272025-01-01131n/an/a10.1002/iid3.70129Serum Alkaline Phosphatase Levels in Pediatric Kikuchi‐Fujimoto Disease: A Retrospective Observational AnalysisShintaro Fujiwara0Yousuke Higuchi1Junya Shimizu2Department of Pediatrics NHO Okayama Medical Center Okayama JapanDepartment of Pediatrics NHO Okayama Medical Center Okayama JapanDepartment of Pediatrics NHO Okayama Medical Center Okayama JapanABSTRACT Aim Kikuchi‐Fujimoto disease (KFD) rarely affects pediatric patients and is characterized by prolonged fever and cervical lymphadenopathy. The diagnosis of KFD remains challenging and often requires an invasive biopsy. Low serum alkaline phosphatase levels have frequently been observed in patients with KFD; however, the clinical significance of low serum alkaline phosphatase levels remains unclear. Methods This retrospective study included pediatric patients aged < 16 years who were pathologically or clinically diagnosed with KFD and infectious mononucleosis between April 2016 and March 2023. Serum alkaline phosphatase levels were analyzed employing age‐ and sex‐specific reference intervals. Clinical and laboratory data were evaluated to determine their association with serum alkaline phosphatase levels. Results Thirty patients with KFD and 23 patients with infectious mononucleosis were included in the study. Seventeen patients with KFD (56.7%) had serum alkaline phosphatase levels below the 2.5th percentile of the age‐ and sex‐specific reference intervals. Serum alkaline phosphatase levels were significantly lower in patients with KFD than in those with infectious mononucleosis. Clinical and other laboratory findings were not significantly different between patients with KFD with or without a decline in serum alkaline phosphatase levels. Conclusion A decrease in serum alkaline phosphatase levels, particularly when assessed as a percentage of age‐ and sex‐specific reference intervals, may be a valuable and noninvasive supportive feature of KFD in pediatric patients.https://doi.org/10.1002/iid3.70129histiocytic necrotizing lymphadenitisinfectious mononucleosisKikuchi‐Fujimoto diseaseserum alkaline phosphatase |
| spellingShingle | Shintaro Fujiwara Yousuke Higuchi Junya Shimizu Serum Alkaline Phosphatase Levels in Pediatric Kikuchi‐Fujimoto Disease: A Retrospective Observational Analysis Immunity, Inflammation and Disease histiocytic necrotizing lymphadenitis infectious mononucleosis Kikuchi‐Fujimoto disease serum alkaline phosphatase |
| title | Serum Alkaline Phosphatase Levels in Pediatric Kikuchi‐Fujimoto Disease: A Retrospective Observational Analysis |
| title_full | Serum Alkaline Phosphatase Levels in Pediatric Kikuchi‐Fujimoto Disease: A Retrospective Observational Analysis |
| title_fullStr | Serum Alkaline Phosphatase Levels in Pediatric Kikuchi‐Fujimoto Disease: A Retrospective Observational Analysis |
| title_full_unstemmed | Serum Alkaline Phosphatase Levels in Pediatric Kikuchi‐Fujimoto Disease: A Retrospective Observational Analysis |
| title_short | Serum Alkaline Phosphatase Levels in Pediatric Kikuchi‐Fujimoto Disease: A Retrospective Observational Analysis |
| title_sort | serum alkaline phosphatase levels in pediatric kikuchi fujimoto disease a retrospective observational analysis |
| topic | histiocytic necrotizing lymphadenitis infectious mononucleosis Kikuchi‐Fujimoto disease serum alkaline phosphatase |
| url | https://doi.org/10.1002/iid3.70129 |
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