LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression

LncRNA SLNCR phenocopies the E2F1 DNA binding site to promote melanoma progression

Summary: The long non-coding RNA SLNCR and the transcription factor E2F1 are known melanoma oncogenes. We show that SLNCR binds to E2F1 to promote the proliferation, invasion, and migration of melanoma cells from the bloodstream into the lungs. Blocking SLNCR-E2F1 complex formation without reducing...

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Bibliographic Details
Main Authors: Kushani Shah, Eleni Anastasakou, Leinal Sejour, Yufei Wang, Leon Wert-Lamas, Christopher Rauchet, Sabine Studer, Simon Goller, Robert J. Distel, Wayne Marasco, Lalith Perera, Ioannis S. Vlachos, Carl D. Novina
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003791
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