Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension

Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension

BackgroundType 2 diabetes mellitus (T2DM) and Hypertension (HTN) frequently coexist and synergistically exacerbate vascular and immune dysfunction. Despite their clinical interrelation, these diseases have traditionally been studied in isolation, and the molecular mechanisms underlying their comorbi...

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Main Authors: Claudia Desireé Norzagaray-Valenzuela, Marco Antonio Valdez-Flores, Josue Camberos-Barraza, Alberto Kousuke De la Herrán-Arita, Juan Fidel Osuna-Ramos, Javier Magaña-Gómez, Carla Angulo-Rojo, Alma Marlene Guadrón-Llanos, Katia Aviña-Padilla, Loranda Calderón-Zamora
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
type 2 diabetes mellitus
hypertension
transcriptomics
Interactomics
coexpression networks
inflammatory pathways
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1621413/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1621413/full

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