The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.
Quantifying the kinetics with which memory T cell populations are generated and maintained is essential for identifying the determinants of the duration of immunity. The quality and persistence of circulating CD4 effector memory (TEM) and central memory (TCM) T cells in mice appear to shift with age...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-08-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002380 |
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| author | M Elise Bullock Thea Hogan Cayman Williams Sinead Morris Maria Nowicka Minahil Sharjeel Christiaan van Dorp Andrew J Yates Benedict Seddon |
| author_facet | M Elise Bullock Thea Hogan Cayman Williams Sinead Morris Maria Nowicka Minahil Sharjeel Christiaan van Dorp Andrew J Yates Benedict Seddon |
| author_sort | M Elise Bullock |
| collection | DOAJ |
| description | Quantifying the kinetics with which memory T cell populations are generated and maintained is essential for identifying the determinants of the duration of immunity. The quality and persistence of circulating CD4 effector memory (TEM) and central memory (TCM) T cells in mice appear to shift with age, but it is unclear whether these changes are driven by the aging host environment, by cell age effects, or both. Here, we address these issues by combining DNA labelling methods, established fate-mapping systems, a novel reporter mouse strain, and mathematical models. Together, these allow us to quantify the dynamics of both young and established circulating memory CD4 T cell subsets, within both young and old mice. We show that that these cells and their descendents become more persistent the longer they reside within the TCM and TEM pools. This behaviour may limit memory CD4 T cell diversity by skewing TCR repertoires towards clones generated early in life, but may also compensate for functional defects in new memory cells generated in old age. |
| format | Article |
| id | doaj-art-95c8fb670bbc40b195dd7e6e7aec8d73 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-95c8fb670bbc40b195dd7e6e7aec8d732025-01-25T05:31:03ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852024-08-01228e300238010.1371/journal.pbio.3002380The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.M Elise BullockThea HoganCayman WilliamsSinead MorrisMaria NowickaMinahil SharjeelChristiaan van DorpAndrew J YatesBenedict SeddonQuantifying the kinetics with which memory T cell populations are generated and maintained is essential for identifying the determinants of the duration of immunity. The quality and persistence of circulating CD4 effector memory (TEM) and central memory (TCM) T cells in mice appear to shift with age, but it is unclear whether these changes are driven by the aging host environment, by cell age effects, or both. Here, we address these issues by combining DNA labelling methods, established fate-mapping systems, a novel reporter mouse strain, and mathematical models. Together, these allow us to quantify the dynamics of both young and established circulating memory CD4 T cell subsets, within both young and old mice. We show that that these cells and their descendents become more persistent the longer they reside within the TCM and TEM pools. This behaviour may limit memory CD4 T cell diversity by skewing TCR repertoires towards clones generated early in life, but may also compensate for functional defects in new memory cells generated in old age.https://doi.org/10.1371/journal.pbio.3002380 |
| spellingShingle | M Elise Bullock Thea Hogan Cayman Williams Sinead Morris Maria Nowicka Minahil Sharjeel Christiaan van Dorp Andrew J Yates Benedict Seddon The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. PLoS Biology |
| title | The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. |
| title_full | The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. |
| title_fullStr | The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. |
| title_full_unstemmed | The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. |
| title_short | The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host. |
| title_sort | dynamics and longevity of circulating cd4 memory t cells depend on cell age and not the chronological age of the host |
| url | https://doi.org/10.1371/journal.pbio.3002380 |
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