The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.

The dynamics and longevity of circulating CD4+ memory T cells depend on cell age and not the chronological age of the host.

Quantifying the kinetics with which memory T cell populations are generated and maintained is essential for identifying the determinants of the duration of immunity. The quality and persistence of circulating CD4 effector memory (TEM) and central memory (TCM) T cells in mice appear to shift with age...

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Main Authors: M Elise Bullock, Thea Hogan, Cayman Williams, Sinead Morris, Maria Nowicka, Minahil Sharjeel, Christiaan van Dorp, Andrew J Yates, Benedict Seddon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002380
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https://doi.org/10.1371/journal.pbio.3002380

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